Intestinal Barrier Disturbances in Haemodialysis Patients: Mechanisms, Consequences, and Therapeutic Options.
Intestinal Barrier Disturbances in Haemodialysis Patients: Mechanisms, Consequences, and Therapeutic Options.
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血液透析患者的肠道障碍：机制，后果和治疗选择。
DOI：
10.1155/2017/5765417
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发表时间：
2017
影响因子：
--
通讯作者：
Burton JO
中科院分区：
文献类型：
--
作者：
March DS;Graham-Brown MP;Stover CM;Bishop NC;Burton JO
越来越多的证据表明，肠道屏障和微生物群可能在 HD 患者的全身炎症中发挥作用。 HD 患者受到许多独特因素的影响，其中一些与 HD 过程有关，另一些则仅与尿毒症环境有关，但其共同特征是它们都可以改变肠道屏障和微生物群。本综述旨在概述目前测量 HD 患者此类变化的方法、这些变化背后的机制以及可能减轻这些变化的潜在策略。最后，透析期间运动是 HD 患者越来越多地采用的干预措施。然而，这对肠道屏障可能产生的潜在影响尚不清楚；因此还涵盖了未来的研究方向。
There is accumulating evidence that the intestinal barrier and the microbiota may play a role in the systemic inflammation present in HD patients. HD patients are subject to a number of unique factors, some related to the HD process and others simply to the uraemic milieu but with common characteristic that they can both alter the intestinal barrier and the microbiota. This review is intended to provide an overview of the current methods for measuring such changes in HD patients, the mechanisms behind these changes, and potential strategies that may mitigate these modifications. Lastly, intradialytic exercise is an increasingly employed intervention in HD patients; however the potential implications that this may have for the intestinal barrier are not known; therefore future research directions are also covered.