Abnormalities of serotonin metabolism and nonpsychotic psychiatric disorders.
Abnormalities of serotonin metabolism and nonpsychotic psychiatric disorders.
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DOI：
10.3109/10401239309148828
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发表时间：
1993-12-01
期刊：
影响因子：
--
通讯作者：
Sheline, Y I
中科院分区：
文献类型：
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作者：
Csernansky, J G;Sheline, Y I
脑5-羟色胺（5-羟色胺；5-HT）代谢异常被认为是抑郁症易感性和长期冲动和攻击倾向的神经生物学基础。采用多种5-羟色胺测量方法的研究结果，包括评估脑脊液5-羟基吲哚乙酸浓度、5-羟色胺摄取部位密度、脑组织和血小板中5-羟色胺2受体密度，以及芬氟拉明给药后泌乳素的增加，为这两种假设提供了支持。未来研究的目标应该是更好地定义5-羟色胺功能障碍在情绪不稳定和冲动中的病理生理作用，从而为这些精神病理状况开发改进的治疗方法。
Abnormalities of brain serotonin (5-hydroxytryptamine; 5-HT) metabolism have been proposed as the neurobiological basis of a vulnerability to depression and of a long-standing tendency toward impulsivity and aggression. Results from studies that have employed a variety of 5-HT measures, including the assessment of cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations, 5-HT uptake site densities, and 5-HT2 receptor densities in brain tissue and on platelets, and prolactin increases following fenfluramine administration, provide support for these two hypotheses. The goal of future research should be to better define the pathophysiological role of 5-HT dysfunction for both mood instability and impulsivity, in the service of developing improved treatments for these psychopathological conditions.