Gastrointestinal stromal tumors in a cohort of Chinese patients in Hong Kong
Gastrointestinal stromal tumors in a cohort of Chinese patients in Hong Kong
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DOI：
10.3748/wjg.v12.i14.2223
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发表时间：
2006-04-14
影响因子：
4.3
通讯作者：
Lau, Lin Kiu
中科院分区：
文献类型：
--
作者：
Chan, Kam Hoi;Chan, Chun Wing;Lau, Lin Kiu
目的：目的：了解香港地区胃肠道间质瘤（GISTs）的发病情况及临床特点，探讨CD 117基因的引入对GISTs发病率的影响。在引入CD 117之前诊断了10例GIST。分析其临床特征、肿瘤特点及治疗。结果：本组患者男26例，女21例，年龄29-87岁，平均66.6岁（SD 13.1）。GIST的患病率为13.4 ~ 15.6/10万，年发病率为1.68 ~ 1.96/10万。在引入CD 117之前和之后，GIST的年发病率分别为1.1/10万人和2.1/10万人。胃（34例，72.3%）是最常见的肿瘤部位，其次是小肠（8例，17.0%），食管（2例，4.3%），大网膜（2例，4.3%）和结肠（1例，2.1%）。31例患者（660%）肿瘤完全切除。16例死亡中有11例（23%）与肿瘤有关。中位生存期26个月。5年生存率为61.3%。与肿瘤相关的死亡或复发的显着因素是不完全切除，肿瘤大小5厘米或以上，侵犯到邻近器官或存在transferation.CONCLUSION：GIST的发病率在香港是可比的，在美国，但低于芬兰。在引入CD 117之前，GIST的真实发病率可能被低估。肿瘤切除不完全、肿瘤大小≥ 5cm、侵犯邻近器官或转移是预测肿瘤相关死亡或复发的因素。(c)2006年，WJG出版社。All rights reserved.
AIM: To investigate the prevalence and clinical pattern of gastrointestinal stromal tumors (GISTs) in Hong Kong Chinese, and to assess the impact of introduction of CD117 on the disease incidence.METHODS: From the database of the Department of Pathology of Yan Chai Hospital, 47 patients, with GISTs from September 1995 to December 2003 were included in this study. Ten GISTs were diagnosed before the introduction of CD117. The clinical features, tumor characteristics, and treatment were analyzed. Factors predicting tumor related death or recurrence were studied with Cox proportional hazard model.RESULTS: The patients included 26 males and 21 females, with a mean age of 66.6 years (SD 13.1, range 29-87 years). The estimated prevalence of GISTs was 13.4-15.6 per 100 000 people, with an annual incidence of 1.68-1.96 per 100 000 people. The annual incidence of GISTs before and after the introduction of CD117 was 1.1 per 100 000 people and 2.1 per 100 000 people respectively. Stomach (34 patients, 72.3%) was the most common location for the tumor, followed by the small intestine (8 patients, 17.0%), esophagus (2 patients, 4.3%), omentum (2 patients, 4.3%) and colon (1 patient, 2.1%). Thirty-one patients (660%) had complete tumor resection. Eleven out of 16 deaths (23%) were tumor-related. The median survival time was 26 mo. Five-year survival rate was 61.3%. The significant factors associated with tumor-related death or recurrence were incomplete resection, tumor size 5 cm or above, invasion to the adjacent organ or presence of metastasis.CONCLUSION: The incidence of GIST in Hong Kong is comparable to that in the United States but lower than that in Finland. The true incidence of GISTs could be underestimated before the introduction of CD117. Incomplete resection, tumor size 5 cm or above, invasion to the adjacent organ or presence of metastasis are factors predicting tumor-related death or recurrence. (c) 2006 The WJG Press. All rights reserved.