THE ASSOCIATION BETWEEN PRENATAL STRESS AND INFANT BIRTH-WEIGHT AND GESTATIONAL-AGE AT BIRTH - A PROSPECTIVE INVESTIGATION
THE ASSOCIATION BETWEEN PRENATAL STRESS AND INFANT BIRTH-WEIGHT AND GESTATIONAL-AGE AT BIRTH - A PROSPECTIVE INVESTIGATION
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DOI：
10.1016/0002-9378(93)90016-c
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发表时间：
1993-10-01
影响因子：
9.8
通讯作者：
GARITE, TJ
中科院分区：
文献类型：
--
作者：
WADHWA, PD;SANDMAN, CA;GARITE, TJ
目的：目的是测试一个模型的产妇产前心理压力对出生结果的影响后，控制生物医学risk.Study设计：在一项前瞻性研究中，一个社会人口统计学同质样本的90名妇女进行了评估，在第三个三个月的标准，可靠的问卷调查，测量情节和慢性压力，应变（压力反应），和妊娠相关的焦虑。出生结局包括婴儿出生体重、出生时胎龄和产时并发症。还对产次和生物医学（产前）风险进行了编码。在控制了生物医学危险因素的影响后，进行了双变量和多变量分析。独立的生物医学风险，每个单位增加产前生活事件的压力（从14.7个单位的可能样本范围）与婴儿出生体重减少55.03克和低出生体重的可能性显着增加有关（比值比1.32），和每个单位的产前妊娠焦虑增加（从一个可能的样本范围5个单位）与3天的胎龄减少birth.CONCLUSION：独立的生物医学风险，产妇产前应激因素显着相关的婴儿出生体重和出生时的胎龄。
OBJECTIVE: The aim was to test a model of the influence of maternal prenatal psychosocial stress on birth outcomes after controlling for biomedical risk.STUDY DESIGN: In a prospective study a sociodemographically homogeneous sample of 90 women was assessed during the third trimester with standard, reliable questionnaires that measured episodic and chronic stress, strain (response to stress), and pregnancy-related anxiety. Birth outcomes included infant birth weight, gestational age at birth, and intrapartum complications. Parity and biomedical (antepartum) risk was also coded. Bivariate and multivariate analyses were performed after controlling for the effects of biomedical risk factors.RESULTS: Independent of biomedical risk, each unit increase of prenatal life event stress (from a possible sample range of 14.7 units) was associated with a 55.03 gm decrease in infant birth weight and with a significant increase in the likelihood of low birth weight (odds ratio 1.32), and each unit increase of prenatal pregnancy anxiety (from a possible sample range of 5 units) was associated with a 3-day decrease in gestational age at birth.CONCLUSION: Independent of biomedical risk, maternal prenatal stress factors are significantly associated with infant birth weight and with gestational age at birth.