Human Prostate Cancer Hallmarks Map.
Human Prostate Cancer Hallmarks Map.
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DOI：
10.1038/srep30691
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发表时间：
2016-08-01
影响因子：
4.6
通讯作者：
Sen P
中科院分区：
文献类型：
--
作者：
Datta D;Aftabuddin M;Gupta DK;Raha S;Sen P
人类前列腺癌是一种复杂的异质性疾病，主要影响西方世界的老年男性人群，具有高死亡率。获得不同的标志性能力沿着雄激素受体信号传导的异常功能是前列腺肿瘤发生及其向转移性去势抵抗性疾病转变的中心驱动力。这些标志性能力的出现是由于几个关键因素的强烈协调，包括重要细胞生理过程的失调，肿瘤抑制活性的失活和前列腺特异性细胞稳态的破坏。前列腺癌中癌蛋白信号传导的分子复杂性和冗余性要求同时抑制多个标志相关途径。通过对已发表的生物医学文献进行广泛的人工整理，我们开发了人类前列腺癌标志图（HPCHM），这是人类前列腺癌相关信号和事件的肿瘤功能图谱。它探讨了前列腺癌信号传导的分子结构在各个层面上，即关键蛋白质组分，分子连接图，致癌信号通路图，基于通路的功能连接图等，在这里，我们简要地代表了系统水平的理解与前列腺肿瘤发生的分子机制，考虑每个和个人的分子和细胞的生物学事件，这种疾病的过程。
Human prostate cancer is a complex heterogeneous disease that mainly affects elder male population of the western world with a high rate of mortality. Acquisitions of diverse sets of hallmark capabilities along with an aberrant functioning of androgen receptor signaling are the central driving forces behind prostatic tumorigenesis and its transition into metastatic castration resistant disease. These hallmark capabilities arise due to an intense orchestration of several crucial factors, including deregulation of vital cell physiological processes, inactivation of tumor suppressive activity and disruption of prostate gland specific cellular homeostasis. The molecular complexity and redundancy of oncoproteins signaling in prostate cancer demands for concurrent inhibition of multiple hallmark associated pathways. By an extensive manual curation of the published biomedical literature, we have developed Human Prostate Cancer Hallmarks Map (HPCHM), an onco-functional atlas of human prostate cancer associated signaling and events. It explores molecular architecture of prostate cancer signaling at various levels, namely key protein components, molecular connectivity map, oncogenic signaling pathway map, pathway based functional connectivity map etc. Here, we briefly represent the systems level understanding of the molecular mechanisms associated with prostate tumorigenesis by considering each and individual molecular and cell biological events of this disease process.