Prognostic significance of body weight variation after diagnosis in ALS: a single-centre prospective cohort study
Prognostic significance of body weight variation after diagnosis in ALS: a single-centre prospective cohort study
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DOI：
10.1007/s00415-019-09276-2
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发表时间：
2019-06-01
影响因子：
6
通讯作者：
Isozaki, Eiji
中科院分区：
文献类型：
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作者：
Shimizu, Toshio;Nakayama, Yuki;Isozaki, Eiji
背景发病后体重减轻是肌萎缩性脊髓侧索硬化症（ALS）生存的独立预测因素，但诊断后体重变化的意义仍有待确定。目的通过前瞻性队列研究探讨 ALS 患者诊断后体重变化及其预后意义。方法 79 例 ALS 患者纳入本研究。在诊断时和大约一年后，我们评估了以下参数：年龄、性别、发病年龄、发病区域、体重指数（BMI）和病前BMI、用力肺活量和修订的ALS功能评定量表。计算了从发病到诊断以及从诊断到大约一年后的年度体重指数下降率（BMI）。对患者进行随访至终点（死亡或气管切开术），并研究BMI与生存之间的关系。结果诊断后BMI为2.0kg/m(2)/年的患者比那些BMI为2.0kg/m(2)/年的患者生存期更短
BackgroundBody weight reduction after disease onset is an independent predictor of survival in amyotrophic lateral sclerosis (ALS), but significance of weight variation after diagnosis remains to be established.ObjectiveTo investigate weight variation after diagnosis and its prognostic significance in patients with ALS as a prospective cohort study.MethodsSeventy-nine patients with ALS were enrolled in this study. At the time of diagnosis and about 1year later, we evaluated the following parameters: age, sex, onset age, onset region, body mass index (BMI) and premorbid BMI, forced vital capacity and the revised ALS functional rating scale. Annual BMI decline rates (BMI) from onset to diagnosis and from diagnosis to about 1year later were calculated. Patients were followed to the endpoints (death or tracheostomy), and the relationships between BMIs and survival were investigated.ResultsPatients with post-diagnostic BMI2.0kg/m(2)/year showed shorter survival length than those with