Endemic and Epidemic Human Alphavirus Infections in Eastern Panama: An Analysis of Population-Based Cross-Sectional Surveys.
Endemic and Epidemic Human Alphavirus Infections in Eastern Panama: An Analysis of Population-Based Cross-Sectional Surveys.
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DOI：
10.4269/ajtmh.20-0408
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Donnelly CA
中科院分区：
文献类型：
--
作者：
Carrera JP;Cucunubá ZM;Neira K;Lambert B;Pittí Y;Liscano J;Garzón JL;Beltran D;Collado-Mariscal L;Saenz L;Sosa N;Rodriguez-Guzman LD;González P;Lescano AG;Pereyra-Elías R;Valderrama A;Weaver SC;Vittor AY;Armién B;Pascale JM;Donnelly CA
Madariaga病毒(MADV)最近在巴拿马与严重的人类疾病有关，密切相关的委内瑞拉马脑炎病毒(VEEV)也在那里传播。2017年6月，达里安省一个社区确认了一例致命的MADV感染。2017年7月，我们对人和蚊子样本进行了横断面疫情调查，对血清进行了甲型病毒抗体和病毒RNA检测。此外，通过对达里安省2012年和2017年的两次血清调查应用催化感染力(FOI)统计模型，我们调查了历史上是否存在地方性或流行性甲型病毒传播。2017年MADV和VEEV IgM血清流行率分别为1.6%和4.4%，免疫球蛋白抗体流行率分别为MADV：13.2%，VEEV：16.8%，UNA病毒(UNAV)：16.0%，Mayaro病毒：1.1%。未检测到活跃的病毒循环。在家庭附近发现了MADV和UNAV感染的证据，这引发了对其媒介和地方性传播循环的质疑。失眠与MADV和VEEV感染相关，抑郁症状与MADV相关，头晕与VEEV和UNAV相关。感染力分析表明，甲型病毒在历史上是地方性传播的，最近在Aruza和Mercadeo分别增加了人对MADV和VEEV的暴露。缺乏额外的神经系统病例表明，严重的MADV和VEEV感染很少发生。我们的结果表明，在过去50年中，巴拿马东部的甲型病毒感染水平较低，但MADV和VEEV感染最近有所增加--可能是在过去十年中。在巴拿马东部的一些地区，MADV和VEEV的地方性感染和暴发似乎在空间上有所不同。
Madariaga virus (MADV) has recently been associated with severe human disease in Panama, where the closely related Venezuelan equine encephalitis virus (VEEV) also circulates. In June 2017, a fatal MADV infection was confirmed in a community of Darien Province. We conducted a cross-sectional outbreak investigation with human and mosquito collections in July 2017, where sera were tested for alphavirus antibodies and viral RNA. In addition, by applying a catalytic, force-of-infection (FOI) statistical model to two serosurveys from Darien Province in 2012 and 2017, we investigated whether endemic or epidemic alphavirus transmission occurred historically. In 2017, MADV and VEEV IgM seroprevalences were 1.6% and 4.4%, respectively; IgG antibody prevalences were MADV: 13.2%, VEEV: 16.8%, Una virus (UNAV): 16.0%, and Mayaro virus: 1.1%. Active viral circulation was not detected. Evidence of MADV and UNAV infection was found near households, raising questions about its vectors and enzootic transmission cycles. Insomnia was associated with MADV and VEEV infections, depression symptoms were associated with MADV, and dizziness with VEEV and UNAV. Force-of-infection analyses suggest endemic alphavirus transmission historically, with recent increased human exposure to MADV and VEEV in Aruza and Mercadeo, respectively. The lack of additional neurological cases suggests that severe MADV and VEEV infections occur only rarely. Our results indicate that over the past five decades, alphavirus infections have occurred at low levels in eastern Panama, but that MADV and VEEV infections have recently increased—potentially during the past decade. Endemic infections and outbreaks of MADV and VEEV appear to differ spatially in some locations of eastern Panama.
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影响因子：
--
作者：
Johnson, B. W.;Kosoy, O.;Weaver, S. C.
通讯作者：
Weaver, S. C.
影响因子：
11.8
作者：
Lednicky J;De Rochars VM;Elbadry M;Loeb J;Telisma T;Chavannes S;Anilis G;Cella E;Ciccozzi M;Okech B;Salemi M;Morris JG Jr
通讯作者：
Morris JG Jr
影响因子：
158.5
作者：
Carrera, Jean-Paul;Forrester, Naomi;Weaver, Scott C.
通讯作者：
Weaver, Scott C.
DOI：
10.4269/ajtmh.1966.15.385
发表时间：
1966-01-01
影响因子：
3.3
作者：
GALINDO, P;SRIHONGSE, S;GRAYSON, MA
通讯作者：
GRAYSON, MA
DOI：
10.1093/infdis/jiv470
发表时间：
2016-02-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Salje H;Cauchemez S;Alera MT;Rodriguez-Barraquer I;Thaisomboonsuk B;Srikiatkhachorn A;Lago CB;Villa D;Klungthong C;Tac-An IA;Fernandez S;Velasco JM;Roque VG Jr;Nisalak A;Macareo LR;Levy JW;Cummings D;Yoon IK
通讯作者：
Yoon IK