Prognostic factors after isolated limb infusion with cytotoxic agents for melanoma
Prognostic factors after isolated limb infusion with cytotoxic agents for melanoma
复制标题
DOI：
10.1245/aso.2002.9.2.127
复制
发表时间：
2002-03-01
影响因子：
3.7
通讯作者：
Thompson, JF
中科院分区：
文献类型：
--
作者：
Lindnér, P;Doubrovsky, A;Thompson, JF
背景：具有细胞毒性剂的孤立肢体融合（ILP）是一种具有显着有效但复杂的技术，用于治疗局部复发和转移性黑色素瘤局限于肢体。孤立的肢体输注（ILI）本质上是一种通过经皮导管进行而无氧进行的低流量ILP，已被开发为更简单的替代方案。方法：审查了ILI治疗的135例患者的结果。审查了治疗率的：回报：经过处理的总体反应率。肢体为85％（完全响应[CR]率为41％，部分响应率为44％）。中位反应持续时间反应为16个月（CR患者24个月）。中位患者生存率为34个月。在患有CR的人中，中位生存期为42个月。 CR率和生存时间随着疾病阶段的增加而下降。年龄> 70岁的患者的总体反应比年轻患者更好。在多变量分析中，与结果改善有关的因素是疾病的较低阶段，最终肢体温度> 37.8级，止血带时间> 40分钟> 40分钟。结论：ILI后反应的频率和持续时间与常规的响应频率和持续时间相当。 ILP。 ILI技术对于可能不适合常规ILP的老年患者特别有用。
Background: Isolated limb pet-fusion (ILP) with cytotoxic agents is a remark-ably effective but complex technique used to treat locally recurrent and metastatic melanoma confined to a limb. Isolated limb infusion (ILI), essentially a low-flow ILP performed without oxygenation via percutaneous catheters, has been developed as a simpler alternative.Methods: The outcome in 135 patients treated by ILI was reviewed.Results: The overall response rate in the treated limb was 85% (complete response [CR] rate 41%, partial response rate 44%). Median response duration response was 16 months (24 months for patients with CR). Median patient survival was 34 months. In those with a CR, the median survival was 42 months. CR rate and survival time decreased with increasing disease stage. Patients aged >70 years had a better overall response than younger patients. On multivariate analysis, factors associated with an improved outcome were a lower stage of disease, a final limb temperature >37.8degreesC, and a tourniquet time >40 minutes.Conclusions: The frequency and duration of responses after ILI were comparable to those achieved by conventional ILP. The ILI technique is particularly useful for older patients who might not be considered suitable for conventional ILP.