Overexpression of Janus kinase 2 protein in extramammary Paget's disease
Overexpression of Janus kinase 2 protein in extramammary Paget's disease
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Janus 激酶 2 蛋白在乳房外佩吉特病中的过度表达
DOI：
10.1093/jjco/hyab062
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发表时间：
2021
影响因子：
2.4
通讯作者：
Hironobu Ihn
中科院分区：
文献类型：
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作者：
Saki Otsuka-Maeda;Myangat Tselmeg Mijiddorj;Ikko Kajihara;Ryoko Sakamoto;Saori Yamada-Kanazawa;Hisashi Kanemaru;Yuki Nishimura;Soichiro Sawamura;Katsunari Makino;Jun Aoi;Takamitsu Makino;Shinichi Masuguchi;Satoshi Fukushima;Hironobu Ihn
乳房外佩吉特病是一种罕见的皮肤恶性肿瘤，主要发生在生殖器农村地区。乳腺外佩吉特病伴远处转移的预后差，但目前尚无有效的治疗方法。由于Janus激酶2作为几种癌症的治疗靶点引起了人们的关注，我们研究了Janus激酶2蛋白的表达及其表达水平与我院53例乳房外佩吉特病患者临床意义之间的关系。免疫组化结果显示，Janus激酶2在乳腺外佩吉特病组织中的阳性率为94.3%（50/53），其表达强度与乳腺浸润程度、淋巴结转移和远处转移有关。基于这些发现，Janus激酶2可能是乳腺外佩吉特病的一个有前途的治疗靶点。
Extramammary Paget’s disease is a rare malignant tumor of the skin that occurs primarily in the genitocrural region. Although the prognosis of extramammary Paget’s disease with distant metastasis is poor, an effective therapy has not been established. Because Janus kinase 2 has attracted attention as a therapeutic target in several cancers, we investigated the expression of the Janus kinase 2 protein and the relationship between its level of expression and clinical significance in 53 patients with extramammary Paget’s disease in our hospital. Immunohistochemistry showed that most extramammary Paget’s disease tissues were positive for Janus kinase 2 (50/53, 94.3%), and the immunostaining intensity of Janus kinase 2 was correlated with the degree of invasiveness, lymph node metastasis and distant metastasis. Based on these findings, Janus kinase 2 may be a promising therapeutic target in extramammary Paget’s disease.