GENETIC-RELATIONSHIP BETWEEN FETAL HB LEVELS IN NORMAL AND ERYTHROPOIETICALLY STRESSED BABOONS
GENETIC-RELATIONSHIP BETWEEN FETAL HB LEVELS IN NORMAL AND ERYTHROPOIETICALLY STRESSED BABOONS
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DOI：
10.1111/j.1365-2141.1981.tb07213.x
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发表时间：
1981-01-01
影响因子：
6.5
通讯作者：
ZWIERS, D
中科院分区：
文献类型：
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作者：
DESIMONE, J;HELLER, P;ZWIERS, D
先前的研究表明，狒狒胎儿 Hb (Hb F) 对溶血性贫血和低压缺氧的反应程度是特定于动物的（高 Hb F 反应者和低 Hb F 反应者），这表明 Hb F 反应受到遗传控制。在这项研究中，55 只成年狒狒（8 岁以上）和 23 只幼年无应激狒狒的 Hb F 水平在 0.02% 至 0.6% 之间变化（静息 Hb F 水平）。其中 29 只动物遭受溶血应激；他们的 Hb F 反应强度与静息 Hb F 水平呈正相关。此外，父母的静息 Hb F 水平与其后代的静息 Hb F 水平呈正相关。在 11 只动物（7 只成年动物和 4 只幼年动物）中，受到造血应激后，Hb F 水平与 F 细胞数量成比例增加。在幼年动物中，计算出的每个 F 细胞的 Hb F 浓度明显高于成年动物。 Hb F 的静息水平可预测 Hb F 对应激性红细胞生成的反应程度。红细胞生成应激中 F 细胞的数量和每个细胞的 Hb F 浓度似乎受到不同机制的调节。
Previous studies showed that the magnitude of the fetal Hb (Hb F) response to hemolytic anemia and hypobaric hypoxia in the baboon is specific to an animal (high and low Hb F responders), suggesting that the Hb F response is under genetic control. In this study Hb F levels in 55 adult (over 8 yr old) and 23 juvenile unstressed baboons varied between 0.02% and 0.6% (resting Hb F levels). Of these animals 29 were subjected to hemolytic stress; the magnitude of their Hb F response was positively correlated with the resting Hb F levels. In addition, the resting levels of Hb F in parents were positively correlated with those of their offspring. In 11 animals, 7 adults and 4 juveniles, subjected to hemopoietic stress the Hb F levels were increased proportionally to the number of F-cells. In juvenile animals the calculated concentration of Hb F per F-cell was markedly higher than in adult animals. The resting level of Hb F is predictive of the magnitude of the Hb F response to stress erythropoiesis. The number of F-cells and the concentration of Hb F per cell in erythropoietic stress appear to be modulated by different mechanisms.