Examining links between cannabis potency and mental and physical health outcomes
Examining links between cannabis potency and mental and physical health outcomes
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DOI：
10.1016/j.brat.2018.11.008
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发表时间：
2019-04-01
影响因子：
4.1
通讯作者：
Conner, Bradley T.
中科院分区：
文献类型：
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作者：
Prince, Mark A.;Conner, Bradley T.
大麻的使用与不必要的健康结果有关，包括焦虑，抑郁，睡眠卫生不良和认知功能紊乱。然而，迄今为止的研究还未能解开这些关系的复杂性，使行为健康服务提供者缺乏明确的治疗方向。一个限制因素可能是大麻使用评估的共同做法。大麻的使用通常按频率评估，即使要估计摄入的精神活性化合物的量，也应该评估效力、数量和给药途径。这项研究是同类研究中的第一项，通过研究大麻效力与行为健康之间的联系（即，身体和心理健康）的结果。使用新统计学分析自我报告的数据，该统计学侧重于效应量和置信区间，而不是零假设显著性检验。研究结果是不一致的，在四个领域（即，人口统计变量、大麻使用变量、心理健康和身体健康）。最有价值的发现是管理方法在理解效力和健康之间的联系方面的重要性。我们观察到“效力谷”（即，一系列的效力，其中产品是不可用的）之间的花效力和浓缩效力。此外，花和浓缩大麻的效力数据崩溃掩盖了大麻效力与行为健康结果之间的重要关系。研究结果表明，为了更充分地了解大麻效力与行为健康结果之间的关系，研究人员应该分别检查不同给药途径的效力。
Cannabis use is associated with unwanted health outcomes, including anxiety, depression, poor sleep hygiene, and disrupted cognitive functioning. However, research to date has not been able to disentangle the complexities of these relations, leaving behavioral health service providers lacking clear direction for treatment. A limiting factor may be the common practices for cannabis use assessment. Cannabis use is typically assessed by frequency, even though to estimate the amount of psychoactive compounds ingested potency, quantity, and route of administration should also be assessed. This study, one of the first of its kind, takes an important step in assessing cannabis use by studying the link between cannabis potency and behavioral health (i.e., physical and mental health) outcomes. Self-reported data were analyzed using the New Statistics, which focuses on effect sizes and confidence intervals, rather than null hypothesis significance testing. Findings were inconsistent, with some positive, some negative, and some trivial associations across four domains (i.e., demographic variables, cannabis use variables, mental health, and physical health). The most valuable discovery was the importance of method of administration in understanding the link between potency and health. We observed a "potency valley" (i.e., a range of potencies for which products were not available) between flower potencies and concentrate potencies. Further, collapsing potency data across flower and concentrated cannabis obscured important relations between cannabis potency and behavioral health outcomes. Findings suggest that to more fully understand the relation between cannabis potency and behavioral health outcomes, researchers should examine potency separately across routes of administration.