Practical High-Throughput Experimentation for Chemists.
Practical High-Throughput Experimentation for Chemists.
复制标题
DOI：
10.1021/acsmedchemlett.7b00165
复制
发表时间：
2017-06-08
影响因子：
4.2
通讯作者：
Shevlin M
中科院分区：
文献类型：
--
作者：
Shevlin M
大量的假设驱动，合理设计的实验是解决复杂化学问题的有力工具。化学高通量实验的概念和实践方面进行了讨论。一个案例研究中的应用高通量实验的一个关键的合成步骤中的药物发现计划和随后的优化的第一个大规模合成的候选药物的例子。
Large arrays of hypothesis-driven, rationally designed experiments are powerful tools for solving complex chemical problems. Conceptual and practical aspects of chemical high-throughput experimentation are discussed. A case study in the application of high-throughput experimentation to a key synthetic step in a drug discovery program and subsequent optimization for the first large scale synthesis of a drug candidate is exemplified.