Endocannabinoids and the neurochemistry of gluttony
Endocannabinoids and the neurochemistry of gluttony
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DOI：
10.1111/j.1365-2826.2008.01762.x
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发表时间：
2008-09-01
影响因子：
3.2
通讯作者：
Kirkham, Tim
中科院分区：
文献类型：
--
作者：
Kirkham, Tim
大麻通过模仿大脑和外周组织中CB1受体的“内源性大麻素”神经调节剂发挥作用。内源性大麻素通过增加对食物的渴望和享受来刺激食欲，并促进能量在脂肪组织中以脂肪的形式沉积。这些发现提高了CB1拮抗剂作为一类新型抗肥胖剂的可能性。
Cannabis exerts its actions by mimicking 'endocannabinoid' neuromodulators at CB1 receptors in brain and peripheral tissues. The endocannabinoids both stimulate appetite by increasing food craving and enjoyment and promote the deposition of energy as fat in adipose tissues. These findings have raised the possibility of CB1 antagonists as a novel class of anti-obesity agents.