Relationship between serum acute-phase proteins and high disease activity in patients with rheumatoid arthritis
Relationship between serum acute-phase proteins and high disease activity in patients with rheumatoid arthritis
复制标题
DOI：
10.2478/v10039-010-0006-7
复制
发表时间：
2010-06-01
影响因子：
2.7
通讯作者：
Szmitkowski, M.
中科院分区：
文献类型：
--
作者：
Cylwik, B.;Chrostek, L.;Szmitkowski, M.
目的：本研究的目的是评估活动评分（DAS 28）在类风湿关节炎patients with RA.Material/Methods：研究进行了27例女性RA和32例对照妇女血清急性时相蛋白和高疾病活动之间的关系。急性时相蛋白分为4个组分：α 1-球蛋白（以α 1-酸性糖蛋白（AGP）和α 1-抗胰蛋白酶（AAT）为代表）、α 2-球蛋白-触珠蛋白（Hp）、β-球蛋白-补体C3（C3）和总转铁蛋白（Tf）、γ-球蛋白-C反应蛋白（CRP）、类风湿因子（RF）和免疫球蛋白G（IgG）。RA患者血清急性时相蛋白水平发生变化。由于浓度的变化，急性期蛋白被置于降级标度中，如下所示：CRP、Hp、AGP、C3、AAT和Tf。急性时相蛋白中无一与RF相关，大部分与ESR密切相关。几乎所有的急性时相蛋白（不含C3）与RA活动（基于DAS 28）密切相关，其在降级量表中的位置如下：CRP，Tf，AGP，Hp和AAT。健康评定问卷评定的残疾程度对AGP、Tf、CRP浓度有影响。血清AGP、AAT和RF水平与患者年龄显著相关。IgG，TP水平，和临床data.Conclusions：在整个面板，CRP和AGP似乎是最有用的生化指标，用于评估RA患者的疾病活动之间没有相关性。
Purpose: The aim of this study was to assess the relationship between serum acute-phase proteins and high disease activity evaluated by activity score (DAS28) in patients with rheumatoid arthritis.Material/Methods: Studies were carried out on 27 females with RA and 32 control women. Acute-phase proteins were divided into 4 fractions as follows: alpha 1-globulins represented by alpha 1-acid glycoprotein (AGP) and alpha 1-antitrypsin (AAT); alpha 2-globulins-haptoglobin (Hp); beta-globulins-complement C3 (C3) and total transferrin (Tf); gamma-globulins-C reactive protein (CRP), rheumatoid factor (RF) and immunoglobulin G (IgG), and determined by immunoturbidimetric methods.Results: The serum levels of acute-phase proteins changed in RA patients. On account of the alterations of concentration, acute-phase proteins are placed in the downgrade scale as follows: CRP, Hp, AGP, C3, AAT and Tf. None of the acute-phase proteins correlated with the RF and the majority of them were closely related to ESR. Almost all of the acute-phase proteins (without C3) were closely related to RA activity (based on DAS28) and their places in the downgrade scale were as follows: CRP, Tf, AGP, Hp and AAT. The degree of disability evaluated by Health Assessment Questionnaire has affected on the concentrations of AGP, Tf and CRP. Serum AGP, AAT and RF levels significantly correlated with the patient's age. No correlations were observed between IgG, TP levels, and clinical data.Conclusions: Among the entire panel, the CRP and AGP appeared to be the most useful biochemical markers for evaluation of the disease activity of patients with RA.