Antibiotic-loaded cement in orthopedic surgery: a review.
Antibiotic-loaded cement in orthopedic surgery: a review.
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DOI：
10.5402/2011/290851
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Crova M
中科院分区：
文献类型：
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作者：
Bistolfi A;Massazza G;Verné E;Massè A;Deledda D;Ferraris S;Miola M;Galetto F;Crova M
骨科手术中的感染是一个严重的问题。抗生素负载骨水泥被开发用于治疗关节置换术感染和选定病例中全关节置换术的松弛。尽管骨水泥广泛应用于骨科，但仍有许多问题尚不清楚或存在争议：细菌粘附和抗生素抗性，加入抗生素后机械性能的改变，影响抗生素从骨水泥中释放的因素和表面的作用，混合骨水泥和抗生素的方法，抗生素的选择和有效性，两种或两种以上抗生素的组合，以及毒性。本文就抗生素骨水泥的性能、优点和缺陷进行了综述。最终目的是为骨科医生在临床实践中正确选择骨水泥提供清晰简明的信息。
Infections in orthopaedic surgery are a serious issue. Antibiotic-loaded bone cement was developed for the treatment of infected joint arthroplasties and for prophylaxes in total joint replacement in selected cases. Despite the widespread use of the antibiotic-loaded bone cement in orthopedics, many issues are still unclear or controversial: bacterial adhesion and antibiotic resistance, modification of mechanical properties which follows the addition of the antibiotic, factors influencing the release of the antibiotic from the cement and the role of the surface, the method for mixing the cement and the antibiotic, the choice and the effectiveness of the antibiotic, the combination of two or more antibiotics, and the toxicity. This review discusses all these topics, focusing on properties, merits, and defects of the antibiotic loaded cement. The final objective is to provide the orthopaedic surgeons clear and concise information for the correct choice of cement in their clinical practice.