Extracellular vesicles derived from pancreatic cancer cells are enriched in the growth factor Midkine
Extracellular vesicles derived from pancreatic cancer cells are enriched in the growth factor Midkine
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DOI：
10.1016/j.jbior.2021.100857
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发表时间：
2022-01-01
影响因子：
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通讯作者：
Falasca, Marco
中科院分区：
文献类型：
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作者：
Casari, Ilaria;Emmanouilidi, Aikaterini;Falasca, Marco
生长因子中期因子是在维甲酸诱导胚胎癌细胞分化过程中发现的一种肝素结合性细胞因子。一些研究指出该蛋白在肿瘤进展中的关键作用以及它在包括胰腺癌在内的不同恶性肿瘤中的高表达。迫切需要新的诊断和治疗工具来治疗这种高度侵袭性和无法治愈的疾病，这种疾病能够转移、逃避诊断和抵制治疗。血清中期因子有望成为一种非常有用的肿瘤标记物和癌症治疗的靶点，因为在各种肿瘤患者中，血清中期因子浓度的升高一直被报道。在这里，我们从胰腺癌细胞系分离的细胞外小泡中发现了高水平的中期因子，并表明它刺激了不表达中期因子的胰腺癌细胞的生长。
The growth factor Midkine is a heparin-binding cytokine originally discovered during the differentiation process induced by the retinoic acid in embryonal carcinoma cells. Several studies pointed out the key role of this protein in tumour progression and its elevated expression in different malignancies, including pancreatic cancer. New diagnostic and therapeutic tools are urgently required to treat this highly aggressive and incurable disease capable of metastasising, evading diagnosis, and resisting therapy. Serum midkine promises to be a very functional tumour marker and a target for cancer treatment as an elevated concentration of serum midkine is consistently reported in patients with various tumours. Here, we identified high levels of midkine in extracellular vesicles isolated from pancreatic cancer cell lines and showed that it stimulates the growth of pancreatic cancer cells not expressing midkine.