The Clinical Investigation of Citrullus colocynthis (L.) Schrad Fruit in Treatment of Type II Diabetic Patients: A Randomized, Double Blind, Placebo-controlled Clinical Trial
The Clinical Investigation of Citrullus colocynthis (L.) Schrad Fruit in Treatment of Type II Diabetic Patients: A Randomized, Double Blind, Placebo-controlled Clinical Trial
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DOI：
10.1002/ptr.2754
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发表时间：
2009-08-01
影响因子：
7.2
通讯作者：
Larijani, B.
中科院分区：
文献类型：
--
作者：
Huseini, H. Fallah;Darvishzadeh, F.;Larijani, B.
Citrullus colocynthis (L.) Schrad 果是伊朗传统草药师用来治疗糖尿病的草药。为了确定其功效和毒性，在 50 名 H 型糖尿病患者中进行了为期 2 个月的临床试验。两组，每组 25 人，接受标准抗糖尿病治疗，分别接受 100 mg C 芋头果胶囊或安慰剂，每天 3 次。每月对患者进行一次随访，并在开始和2个月后测定糖化血红蛋白（HbA1c）、空腹血糖、总胆固醇、LDL、HDL、甘油三酯、天冬氨酸转氨酶、丙氨酸转氨酶、碱性磷酸酶、尿素和肌酐水平。结果显示，接受 C. colocynthis 治疗的患者的 HbA1c 和空腹血糖水平显着降低。两组其他血清学参数水平均无显着变化。两组均未观察到明显的胃肠道副作用。总之，C colocynthis 水果治疗对改善 11 型糖尿病患者的血糖状况具有有益作用，且没有严重的副作用。建议进行进一步的临床研究来评估 C colocynthis 对糖尿病患者的长期疗效和毒性。版权所有 (C) 2009 John Wiley & Sons, Ltd.
Citrullus colocynthis (L.) Schrad fruit is an herbal medicine used by traditional herbalists for the treatment of diabetes in Iran. To determine its efficacy and toxicity, a 2 month clinical trial was conducted in 50 type H diabetic patients. Two groups of 25 each under standard antidiabetic therapy, received 100 mg C colocynthis fruit capsules or placebos three times a day, respectively. The patients were visited monthly and glycosylated hemoglobin (HbA1c), fasting blood glucose, total cholesterol, LDL, HDL, triglyceride, aspartate transaminase, alanine transaminase, alkaline phosphatase, urea and creatinine levels were determined at the beginning and after 2 months. The results showed a significant decrease in HbA1c and fasting blood glucose levels in C. colocynthis treated patients. Other serological parameters levels in both the groups did not change significantly. No notable gastrointestinal side effect was observed in either group. In conclusion, C colocynthis fruit treatment had a beneficial effect on improving the glycemic profile without severe adverse effects in type 11 diabetic patients. Further clinical studies are recommended to evaluate the long-term efficacy and toxicity of C colocynthis in diabetic patients. Copyright (C) 2009 John Wiley & Sons, Ltd.