EMX1 homeoprotein is expressed in cell nuclei of the developing cerebral cortex and in the axons of the olfactory sensory neurons
EMX1 homeoprotein is expressed in cell nuclei of the developing cerebral cortex and in the axons of the olfactory sensory neurons
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DOI：
10.1016/0925-4773(96)00544-8
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发表时间：
1996-07-01
影响因子：
2.6
通讯作者：
Corte, G
中科院分区：
文献类型：
--
作者：
Briata, P;DiBlas, E;Corte, G
我们分析了EMX 1在小鼠发育过程中的分布。EMX1是由Emx1编码的同源异型蛋白，Emx1是在发育中的前脑中表达的调节性同源异型盒基因。它的分布基本上重叠的Emx1转录本的表达域。EMX1蛋白存在于发育中的端脑背侧，即大脑皮层、嗅球和海马中。在大脑皮层中，EMX1存在于属于所有皮层层的增殖、分化和最成熟的神经元的核中。在嗅球中，它存在于发育过程中的所有增殖细胞中，而出生后，它在一些僧帽细胞中微弱表达。非脑定位包括鳃囊、发育肢体的顶端外胚层嵴和发育肾脏中的瞬时表达。特别令人感兴趣的是EMX1在嗅神经中的存在，从胚胎发育到出生期间的第一次出现。这种蛋白质存在于嗅觉感觉神经元的轴突中，沿着它们的整个长度，包括它们在嗅球中被称为肾小球的神经球的球形区域中的末端。
We analyzed the distribution of EMX1 during mouse development. EMX1 is a homeoprotein encoded by Emx1, a regulatory homeobox gene expressed in the developing forebrain. Its distribution essentially overlaps the expression domains of Emx1 transcripts. The EMX1 protein is present in the developing dorsal telencephalon, that is, in the cerebral cortex, olfactory bulb and hippocampus. In the cerebral cortex EMX1 is present in nuclei of proliferating, differentiating and most mature neurons belonging to all cortical layers. In the olfactory bulb it is present in all proliferating cells during development, whereas postnatally it is faintly expressed in some mitral cells. Non-cerebral localizations include a transient expression in branchial pouches, in the apical ectodermal ridge of the developing limbs and in the developing kidney. Of particular interest is the presence of EMX1 in the olfactory nerve from its first appearance during embryogenesis to birth. The protein is present in axons of olfactory sensory neurons along their entire length, including their terminals in spherical regions of neuropil in the olfactory bulb called glomeruli.