The Ysa type 3 secretion system of Yersinia enterocolitica biovar 1B.
The Ysa type 3 secretion system of Yersinia enterocolitica biovar 1B.
复制标题
小肠结肠炎耶尔森菌生物变种 1B 的 Ysa 3 型分泌系统。
DOI：
10.1007/978-0-387-72124-8_26
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发表时间：
2007
影响因子：
--
通讯作者：
Young,GlennM
中科院分区：
文献类型：
--
作者：
Young,GlennM
耶尔森氏肠炎耶尔森氏菌维持着两个不同的、独立运行的T3S分泌系统，能够将有毒的效应蛋白转移到哺乳动物细胞中。这些T3系统中的每一个都通过影响感染的不同阶段而在感染的结果中发挥作用。最近对Ysa T3S系统的研究表明，这是一个重要的领域。肠道政治在感染的胃肠道阶段存活。这使该系统有别于YSC T3S系统，后者对系统性感染非常重要。效应器蛋白的鉴定为Ysa T3S系统如何调控Y提供了洞察力。肠道政治与宿主的相互作用。在一定程度上，Ysa T3S系统针对的是先天免疫反应，以抑制宿主迅速清除感染的能力。
Yersinia enterocoliticabiovar 1B maintains two distinct and independently operating type 3 secretion (T3S) systems with the capacity to translocate toxic effector proteins into mammalian cells. Each of these T3S systems plays a role in the outcome of an infection by influencing different stages of infection. Recent investigations of the Ysa T3S system have revealed it is important forY. enterocoliticasurvival during the gastrointestinal phase of infection. This sets this system apart from the Ysc T3S system which is important for systemic infections. Identification of the effector proteins has provided insight on how the Ysa T3S system modulatesY. enterocoliticainteractions with the host. In part, the Ysa T3S system targets the innate immune response to suppress the ability of the host to rapidly clear an infection.