Nocturnal elevation of intraocular pressure is detectable in the sitting position
Nocturnal elevation of intraocular pressure is detectable in the sitting position
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DOI：
10.1167/iovs.03-0349
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发表时间：
2003-10-01
影响因子：
4.4
通讯作者：
Weinreb, RN
中科院分区：
文献类型：
--
作者：
Liu, JHK;Bouligny, RP;Weinreb, RN
目的。当在24小时内监测仰卧位健康青年的眼压(IOP)时，可以观察到从白天到夜间的眼压升高。这项研究是为了研究当实验对象坐着时是否也能检测到类似的眼压升高。排除近视3D以上的受试者。他们被关在一个睡眠实验室里，在严格控制的环境中24小时。根据每个志愿者习惯的睡眠周期，为每个志愿者分配了8小时的夜间/睡眠时间。用气压计每隔2小时测量一次眼压，志愿者分别在坐姿和仰卧位下测量眼压。比较坐位和仰位眼压数据的平均昼夜眼压变化和余弦拟合24小时眼压节律。结果：坐位和仰位眼压在夜间的平均眼压均显著高于白天/觉醒时段。24小时眼压低谷出现在昼夜节律末期，峰值出现在夜间节律末期。谷峰差值：坐位3.8+/-0.6 mm Hg，仰卧位3.4+/-0.6 mm Hg。24小时眼压数据的余弦拟合显示，该组坐位和仰卧位IOPS的24小时节律是同步的。坐位和仰卧位两种24小时节律眼压的时相和变化幅度无差异。结论：健康青年在坐位和仰卧位均可检测到夜间眼压升高。坐式眼压的24小时节律与仰卧式眼压的24小时节律没有什么不同。
PURPOSE. When intraocular pressure (IOP) was monitored in supine healthy young adults throughout a 24-hour period, a diurnal-to-nocturnal elevation of IOP was observed. This study was undertaken to investigate whether a similar elevation of IOP can be detected when experimental subjects are in the sitting position.METHODS. Experimental subjects were 16 nonsmoking, healthy young volunteers (ages, 18 -25 years). Subjects with myopia of more than 3 D were excluded. They were housed in a sleep laboratory for 24 hours in a strictly controlled environment. An 8-hour nocturnal/sleep period was assigned to each volunteer according to the individual's accustomed sleep cycle. IOP was measured every 2 hours with a pneumatonometer with the volunteers in both sitting and supine positions. Mean diurnal-to-nocturnal IOP change and the cosine-fit 24-hour IOP rhythm were compared between the sitting and the supine IOP data.RESULTS. Mean IOP was significantly higher in the nocturnal period than in the diurnal/wake period for both the sitting and the supine IOPs. The 24-hour IOP troughs appeared at the end of the diurnal period, and the peaks appeared at the end of the nocturnal period. The difference between the trough and the peak was 3.8 +/- 0.6 mm Hg (mean +/- SEM) in the sitting position and 3.4 +/- 0.6 mm Hg in the supine position. Cosine-fitting of 24-hour IOP data showed a synchronized 24-hour rhythm of the sitting and the supine IOPS for the group. There was no difference in the phase timing or the magnitude of variation between these two 24-hour rhythms of sitting and supine IOPs.CONCLUSIONS. A nocturnal elevation of IOP can be detected in healthy young adults in both the sitting and the supine positions. There is a 24-hour rhythm of sitting IOP that is not different from the 24-hour rhythm of supine IOP.