FLUID-FLOW STIMULATES TISSUE PLASMINOGEN-ACTIVATOR SECRETION BY CULTURED HUMAN-ENDOTHELIAL CELLS
FLUID-FLOW STIMULATES TISSUE PLASMINOGEN-ACTIVATOR SECRETION BY CULTURED HUMAN-ENDOTHELIAL CELLS
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DOI：
10.1126/science.2467379
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发表时间：
1989-03-17
期刊：
影响因子：
56.9
通讯作者：
MCINTIRE, LV
中科院分区：
文献类型：
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作者：
DIAMOND, SL;ESKIN, SG;MCINTIRE, LV
血流产生的壁剪切应力可能调节内皮细胞对纤溶蛋白的表达。体外培养的人内皮细胞分泌组织型纤溶酶原激活剂（tPA）和1型纤溶酶原激活剂抑制剂（PAI-1）不受静脉剪应力（4 dynes/cm2）的影响。然而，在动脉剪应力为15和25 dyes /cm2时，tPA分泌率分别是基础tPA分泌率的2.1和3.0倍。在整个生理范围内，PAI-1的分泌不受剪切应力的影响。
Wall shear stress generated by blood flow may regulate the expression of fibrinolytic proteins by endothelial cells. Tissue plasminogen activator (tPA) and plasminogen activator inhibitor, type 1 (PAI-1) secretion by cultured human endothelial cells were not affected by exposure to venous shear stress (4 dynes/cm2). However, at arterial shear stresses of 15 and 25 dynes/cm2, the tPA secretion rate was 2.1 and 3.0 times greater, respectively, than the basal tPA secretion rate. PAI-1 secretion was unaffected by shear stress over the entire physiological range.