BILATERAL COLLICULAR INTERACTION: MODULATION OF AUDITORY SIGNAL PROCESSING IN FREQUENCY DOMAIN
BILATERAL COLLICULAR INTERACTION: MODULATION OF AUDITORY SIGNAL PROCESSING IN FREQUENCY DOMAIN
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双边交互：频域听觉信号处理的调制
DOI：
10.1016/j.neuroscience.2013.01.011
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发表时间：
2013-04-03
期刊：
影响因子：
3.3
通讯作者：
Chen, Q. -C.
中科院分区：
文献类型：
--
作者：
Cheng, L.;Mei, H. -X.;Chen, Q. -C.
在上行听觉通路中，下丘(IC)通过下丘和听皮质的连合，接受和整合来自各种下层听觉核团的兴奋性和抑制性输入，内源性投射在下丘内，对侧丘通过下丘和听皮质的连合接受和整合。所有这些联系使IC成为皮层下时间和频谱整合听觉信息的主要中心。在本研究中，我们利用电生理记录和局部电刺激，研究了双侧丘脑相互作用在小鼠频域信号处理中的调制作用。对一个IC中的神经元进行局部电刺激会对另一个IC中的神经元的反应产生广泛的抑制和集中的促进作用。这种双侧丘脑相互作用降低了受抑IC神经元的反应幅度，延长了反应潜伏期，但对易化IC神经元的反应却产生了相反的影响。在频域中，一个IC的局域电刺激使另一个IC中神经元的频率调谐曲线(FTC)锐化或扩展，以提高频率灵敏度和频率响应范围。局灶电刺激还使调制IC(ICmdu)神经元的最佳频率(BF)向电刺激IC(ICES)神经元的最佳频率(BF)移动。双侧丘脑相互作用的程度取决于ICES神经元和ICmDU神经元之间BF的差异。这些数据表明，双侧纹状体相互作用是动态声信号处理的一部分，它根据声学经验调整和改进信号处理，并重组信号参数的纹状体表示。(C)2013年IBRO。爱思唯尔有限公司出版。保留所有权利。
In the ascending auditory pathway, the inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from a variety of lower auditory nuclei, intrinsic projections within the IC, contralateral IC through the commissure of the IC and the auditory cortex. All these connections make the IC a major center for subcortical temporal and spectral integration of auditory information. In this study, we examine bilateral collicular interaction in the modulation of frequencydomain signal processing of mice using electrophysiological recording and focal electrical stimulation. Focal electrical stimulation of neurons in one IC produces widespread inhibition and focused facilitation of responses of neurons in the other IC. This bilateral collicular interaction decreases the response magnitude and lengthens the response latency of inhibited IC neurons but produces an opposite effect on the response of facilitated IC neurons. In the frequency domain, the focal electrical stimulation of one IC sharpens or expands the frequency tuning curves (FTCs) of neurons in the other IC to improve frequency sensitivity and the frequency response range. The focal electrical stimulation also produces a shift in the best frequency (BF) of modulated IC (ICmdu) neurons toward that of electrically stimulated IC (ICES) neurons. The degree of bilateral collicular interaction is dependent upon the difference in the BF between the ICES neurons and ICmdu neurons. These data suggest that bilateral collicular interaction is a part of dynamic acoustic signal processing that adjusts and improves signal processing as well as reorganizes collicular representation of signal parameters according to the acoustic experience. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.