G-CSF receptor-mediated up-regulation of c-fos but not c-raf mRNA expression in myeloid cells.
G-CSF receptor-mediated up-regulation of c-fos but not c-raf mRNA expression in myeloid cells.
复制标题
G-CSF 受体介导的骨髓细胞中 c-fos mRNA 表达上调，但不上调 c-raf mRNA 表达。
DOI：
10.1023/a:1006894329316
复制
发表时间：
1998
影响因子：
4.3
通讯作者：
Moore,MA
中科院分区：
文献类型：
--
作者：
Deshpande,RV;Moore,MA
Granulocyte colony stimulating factor (G-CSF) regulates survival, proliferation, and differentiation of myeloid precursor cells. One of the signaling mechanisms for the G-CSF receptor (G-CSF-R) involves the activation of Ras/MAP kinase (MEK) pathway. Since Raf is an important, common link between Ras and MEK in the Ras-Raf-MEK cascade, we studied the expression of c-raf mRNA in G-CSF-treated myeloid precursor cell lines - NFS-60 and HL-60. G-CSF did not alter c-raf mRNA expression in these cells up to 24 h, but induced a transient up-regulation of c-fos mRNA expression between 15-60 min post-treatment. Our results show that G-CSF triggers a de novo induction of c-fos but not c-raf mRNA, and suggests that G-CSF-R-mediated activation of Ras/MEK pathway may involve post-transcriptional mechanisms of Raf regulation.
