Cortical glucose metabolism correlates negatively with delta-slowing and spike-frequency in epilepsy associated with tuberous sclerosis.
Cortical glucose metabolism correlates negatively with delta-slowing and spike-frequency in epilepsy associated with tuberous sclerosis.
复制标题
皮质葡萄糖代谢与结节性硬化症相关癫痫的 Delta 减慢和尖峰频率呈负相关。
DOI：
10.1002/hbm.20461
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发表时间：
2008
影响因子：
4.8
通讯作者：
Chugani,HarryT
中科院分区：
文献类型：
--
作者：
Nishida,Masaaki;Asano,Eishi;Juhász,Csaba;Muzik,Otto;Sood,Sandeep;Chugani,HarryT
局灶性癫痫患者正电子发射断层扫描（PET）显示的葡萄糖代谢改变的机制尚未完全清楚。我们使用PET和皮质电图（ECoG）测量了11名接受癫痫手术的结节性硬化症（TSC）相关局灶性癫痫患儿（年龄：0.5-16岁）的865个颅内电极部位，确定了发作间期葡萄糖代谢和发作间期神经元活动之间的相关性。对每例患者进行多元线性回归分析，以确定发作间期PET上每个电极部位的葡萄糖摄取是否可通过在给定电极部位测量的ECoG振幅功率和发作间期尖峰频率预测。最终对11名患者的回归斜率和R平方值（回归模型拟合度的指标）进行平均。δ振幅功率的平均回归斜率为−0.0025（95% CI：−0.0045至−0.0004;基于单样本检验，P= 0.02），棘波频率的平均回归斜率为−0.023（95% CI：−0.042至−0.0038;P= 0.02）。另一方面，其余ECoG振幅功率（θ、α、σ、β和γ活动）的平均回归斜率与零无显著差异。平均R2值为0.39。这些结果表明，在TSC相关局灶性癫痫儿童中，δ减慢和频繁棘波活动增加与葡萄糖代谢低下独立和叠加相关。频繁发作间期峰电位活动与低葡萄糖代谢之间的关联可能归因于ECoG记录上峰电位放电后的慢波成分，PET上局部葡萄糖代谢的大部分变化可以通过传统硬膜下ECoG记录的电生理特征来解释。《大脑地图》，2008年。© 2007 Wiley利斯公司
The mechanism of altered glucose metabolism seen on positron emission tomography (PET) in focal epilepsy is not fully understood. We determined the association between interictal glucose metabolism and interictal neuronal activity, using PET and electrocorticography (ECoG) measures derived from 865 intracranial electrode sites in 11 children with focal epilepsy associated with tuberous sclerosis complex (TSC) (age: 0.5–16 years) undergoing epilepsy surgery. A multiple linear regression analysis was applied to each patient, to determine whether the glucose uptake at each electrode site on interictal PET was predicted by ECoG amplitude powers and interictal spike‐frequency measured in the given electrode site. The regression slopes as well asR‐square values (an indicator of fitness of the regression models) were finally averaged across the 11 patients. The mean regression slope for delta amplitude power was −0.0025 (95% CI: −0.0045 to −0.0004;P= 0.02 based on one‐samplet‐test) and that for spike frequency was −0.023 (95% CI: −0.042 to −0.0038;P= 0.02). On the other hand, the mean regression slopes for the remaining ECoG amplitude powers (theta, alpha, sigma, beta, and gamma activities) were not significantly different from zero. The meanR‐square value was 0.39. These results suggest that increased delta‐slowing and frequent spike activity were independently and additively associated with glucose hypometabolism in children with focal epilepsy associated with TSC. Association between frequent interictal spike activity and low glucose metabolism may be attributed to slow‐wave components following spike discharges on ECoG recording, and a substantial proportion of the variance in regional glucose metabolism on PET could be explained by electrophysiological traits derived from conventional subdural ECoG recording. Hum Brain Mapp, 2008. © 2007 Wiley‐Liss, Inc.