Characterization of H5N1 highly pathogenic avian influenza virus strains isolated from migratory waterfowl in Mongolia on the way back from the southern Asia to their northern territory
Characterization of H5N1 highly pathogenic avian influenza virus strains isolated from migratory waterfowl in Mongolia on the way back from the southern Asia to their northern territory
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DOI：
10.1016/j.virol.2010.07.007
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发表时间：
2010-10-10
期刊：
影响因子：
3.7
通讯作者：
Kida, Hiroshi
中科院分区：
文献类型：
--
作者：
Sakoda, Yoshihiro;Sugar, Sengee;Kida, Hiroshi
H5 N1高致病性禽流感病毒分别于2005年7月、2006年5月、2009年5月、2009年7月和2010年5月从蒙古国Khunt、Erkhel、Doityn Tsagaan、Doroo和Ganga Lakes的死亡野生水禽中分离出来。2005年和2006年的分离物属于2.2分支，2009年和2010年的分离物属于2.3.2分支。A/whooper swan/Mongolia/6/2009（H5 N1）实验感染鸭并系统复制，死亡率高于2005年和2006年的分离株。对每年秋季从西伯利亚筑巢湖泊飞往蒙古的迁徙水鸟的禽流感密切监测表明，高致病性禽流感病毒直到2009年才在其筑巢湖泊中永久存在。目前的结果表明，野生水禽零星感染H5 N1高致病性禽流感病毒流行的家禽在南亚和蒙古的途中死亡的北领地在春季。(C)2010年爱思唯尔公司All rights reserved.
H5N1 highly pathogenic avian influenza (HPAI) viruses were isolated from dead wild waterfowl at Khunt, Erkhel, Doityn Tsagaan, Doroo, and Ganga Lakes in Mongolia in July 2005, May 2006, May 2009, July 2009, and May 2010, respectively. The isolates in 2005 and 2006 were classified into genetic clade 2.2, and those in 2009 and 2010 into clade 2.3.2. A/whooper swan/Mongolia/6/2009 (H5N1) experimentally infected ducks and replicated systemically with higher mortality than that of the isolates in 2005 and 2006. Intensive surveillance of avian influenza in migratory waterfowl flying from their nesting lakes in Siberia to Mongolia in every autumn indicate that HPAI viruses have not perpetuated at their nesting lakes until 2009. The present results demonstrate that wild waterfowl were sporadically infected with H5N1 HPAI viruses prevailing in domestic poultry in the southern Asia and died in Mongolia on the way back to their northern territory in spring. (C) 2010 Elsevier Inc. All rights reserved.