Incidence of retinoblastoma in Dutch children conceived by IVF: an expanded study
Incidence of retinoblastoma in Dutch children conceived by IVF: an expanded study
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DOI：
10.1093/humrep/dep335
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发表时间：
2009-12-01
影响因子：
6.1
通讯作者：
Moll, A. C.
中科院分区：
文献类型：
--
作者：
Marees, T.;Dommering, C. J.;Moll, A. C.
2003年，我们报告了1995至2002年间接受体外受精的儿童患视网膜母细胞瘤的风险增加。然而，在通过体外受精受孕的儿童中进行的基于人群的研究没有发现视网膜母细胞瘤的风险增加。根据全国通过体外受精受孕的活产数量的估计(n=40330)，我们估计了1995-2007年期间通过体外受精受孕的视网膜母细胞瘤患者的预期数量。通过向1995-2005年间被诊断为视网膜母细胞瘤的儿童的父母发送问卷，获得了观察到的体外受精受孕儿童中诊断为视网膜母细胞瘤的数量。对于无反应者和2005年后确诊的患者，可以通过医疗档案获得信息，自2000年以来，关于生育治疗的信息一直被常规记录在这些档案中。在整个研究期间(1995-2007)和扩大研究期间(2002-2007)，计算了接受体外受精的儿童患视网膜母细胞瘤的相对风险(RR)。在1995-2007年期间诊断的所有符合条件的视网膜母细胞瘤患者(n=162)中，有7人是通过体外受精受孕的。在整个研究期间(1995-2007)，风险显著增加[RR=2.54，95%可信区间=1.02-5.23]。在扩大的研究期间(2002-2007)，没有发现显著增加的风险(RR=1.29，95%CI=0.16-4.66)。我们发现在整个研究期间，接受体外受精的儿童患视网膜母细胞瘤的风险显著增加。然而，这种增加的风险主要是基于以前观察到的1995-2002年的更大的风险增加。在我们的知识的这个阶段，谨慎和觉察，另一方面避免不必要的担忧是重要的。
In 2003, we reported an increased risk of retinoblastoma in children conceived by IVF between 1995 and 2002. However, population-based studies among children conceived by IVF did not find an elevated risk of retinoblastoma.From nationwide estimates of numbers of live births conceived by IVF (n = 40 330), we estimated the expected numbers of patients with retinoblastoma conceived by IVF in the period 1995-2007. The observed number of retinoblastoma diagnoses in children conceived by IVF was obtained by questionnaires sent to the parents of children with retinoblastoma diagnosed between 1995 and 2005. For non-responders and patients diagnosed after 2005, information was available through the medical files, in which information on fertility treatment has been routinely recorded since 2000. The relative risk (RR) of retinoblastoma among children conceived by IVF was calculated for the total study period (1995-2007) and for the expanded study period (2002-2007).Of all eligible patients with retinoblastoma (n = 162) diagnosed in the period 1995-2007, seven were conceived by IVF. In the total study period (1995-2007) the risk was significantly elevated [RR = 2.54, 95% confidence interval (CI) = 1.02-5.23]. In the expanded study period (2002-2007), no significantly elevated risk (RR = 1.29, 95% CI = 0.16-4.66) was found.We found a significantly increased risk of retinoblastoma in children conceived by IVF in the total study period 1995-2007. However, this increased risk was mostly based on the much stronger risk increase observed previously, for 1995-2002. Caution and awareness on the one hand and avoiding unnecessary worries on the other hand are important at this stage of our knowledge.