SIGNIFICANCE OF PIP2 HYDROLYSIS AND REGULATION OF PHOSPHOLIPASE-C ISOZYMES
SIGNIFICANCE OF PIP2 HYDROLYSIS AND REGULATION OF PHOSPHOLIPASE-C ISOZYMES
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DOI：
10.1016/0955-0674(95)80026-3
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发表时间：
1995-04-01
影响因子：
7.5
通讯作者：
RHEE, SG
中科院分区：
文献类型：
--
作者：
LEE, SB;RHEE, SG
磷脂酰肌醇4,5-二磷酸（PIP2）是几种细胞内信号通路的重要组成部分。它作为磷脂酶C的底物，产生第二信使肌醇1,4,5-三磷酸和二酰基甘油。它也是磷脂酰肌醇3-激酶的底物，并调节许多肌动蛋白结合蛋白的功能。PIP2最近被证明是磷脂酰胆碱特异性磷脂酶D的辅助因子，也是许多含有pleckstrin同源结构域的信号蛋白的膜附着位点。严格调节PIP2细胞浓度的必要性部分反映在至少有十种不同的哺乳动物磷脂酶C同工酶和多种机制将这些同工酶与各种受体连接起来的事实。
Phosphatidylinositol 4,5-bisphosphate (PIP2) is an important component of several intracellular signaling pathways. It serves as a substrate for phospholipase C, which produces the second messengers inositol 1,4,5-trisphosphate and diacylglycerol. It is also a substrate for a phosphatidylinositol 3-kinase, and regulates the function of a number of actin-binding proteins. PIP2 has been shown recently to serve as a cofactor for a phosphatidylcholine-specific phospholipase D and as a membrane-attachment site for many signaling proteins containing pleckstrin homology domains. The need to stringently regulate the cellular concentration of PIP2 is reflected in part by the fact that there are at least ten distinct mammalian phospholipase C isozymes and multiple mechanisms linking these isozymes to various receptors.