Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56,307 individuals from the HUNT study in Norway.
Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56,307 individuals from the HUNT study in Norway.
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DOI：
10.1038/ejhg.2013.26
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发表时间：
2013-11
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影响因子：
--
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中科院分区：
文献类型：
--
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遗传学研究表明，染色体 15q25 上的单核苷酸多态性与吸烟相关的性状和疾病之间存在关联，例如吸烟量、肺癌和慢性阻塞性肺病 (COPD)。讨论的重点是这些变异及其与疾病直接相关或通过尼古丁成瘾间接相关的影响。为了解决这些差异，我们对来自挪威北特伦德拉格健康研究 (HUNT) 大型同质人群队列的 56–307 名个体的染色体 15q25 的 CHRNA5/A3/B4 基因簇中的单核苷酸多态性 rs16969968 进行了基因分型。该变体与四种不同的结果相关：肺癌、相当于慢性阻塞性肺病的肺功能丧失、吸烟行为和使用无烟烟草（鼻烟）。在 rs16969968 与开始使用鼻烟的动机因素以及鼻烟使用量之间发现了新的关联。我们的结果还证实并扩展了之前关于 rs16969968 与肺癌、相当于 COPD 的肺功能丧失以及吸烟量之间关联的发现。我们的数据表明 rs16969968 在尼古丁成瘾中发挥作用，而与鼻烟的新关联强化了这一观察结果。
Genetic studies have shown an association between single-nucleotide polymorphisms on chromosome 15q25 and smoking-related traits and diseases, such as quantity of smoking, lung cancer and chronic obstructive pulmonary disease (COPD). A discussion has centred on the variants and their effects being directly disease related or indirect via nicotine addiction. To address these discrepancies, we genotyped the single-nucleotide polymorphism rs16969968 in the CHRNA5/A3/B4 gene cluster at chromosome 15q25, in 56 307 individuals from a large homogenous population-based cohort, the North Trøndelag Health Study (HUNT) in Norway. The variant was examined in relation to four different outcomes: lung cancer, loss of lung function equivalent to that of COPD, smoking behaviour and the use of smokeless tobacco (snus). Novel associations were found between rs16969968 and the motivational factor for starting to use snus, and the quantity of snus used. Our results also confirm and extend previous findings for associations between rs16969968 and lung cancer, loss of lung function equivalent to that of COPD, and smoking quantity. Our data suggest a role for rs16969968 in nicotine addiction, and the novel association with snus strengthens this observation.
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影响因子：
11.2
作者：
Broderick P;Wang Y;Vijayakrishnan J;Matakidou A;Spitz MR;Eisen T;Amos CI;Houlston RS
通讯作者：
Houlston RS
影响因子：
24.3
作者：
Langhammer, A;Johnsen, R;Bjermer, L
通讯作者：
Bjermer, L
影响因子：
4.5
作者：
Pillai SG;Ge D;Zhu G;Kong X;Shianna KV;Need AC;Feng S;Hersh CP;Bakke P;Gulsvik A;Ruppert A;Lødrup Carlsen KC;Roses A;Anderson W;Rennard SI;Lomas DA;Silverman EK;Goldstein DB;ICGN Investigators
通讯作者：
ICGN Investigators
影响因子：
7.7
作者：
Krokstad, S.;Langhammer, A.;Holmen, J.
通讯作者：
Holmen, J.
影响因子：
64.8
作者：
Hung, Rayjean J.;Mckay, James D.;Brennan, Paul
通讯作者：
Brennan, Paul