Calibration of a subcutaneous amperometric glucose sensor implanted for 7 days in diabetic patients - Part 2. Superiority of the one-point calibration method
Calibration of a subcutaneous amperometric glucose sensor implanted for 7 days in diabetic patients - Part 2. Superiority of the one-point calibration method
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DOI：
10.1016/s0956-5663(01)00304-9
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发表时间：
2002-08-01
影响因子：
12.6
通讯作者：
Ward, WK
中科院分区：
文献类型：
--
作者：
Choleau, C;Klein, JC;Ward, WK
校准，即将葡萄糖传感器在时间 t 生成的信号 I(t) 实时转换为葡萄糖浓度 G(t) 的估计值，是连续血糖监测系统开发的关键问题。目的：比较两种校准程序。在单点校准中，假设 10 可以忽略不计，S 简单地确定为比率 I/G，并且 G(t) = I(t)/S。两点校准在于通过绘制传感器信号的两个值与伴随的血糖浓度的关系来确定传感器灵敏度S和背景电流I。随后的 G(t) 估计由 G(t) = (I(t)-I-o)/S 给出。研究设计和方法：将葡萄糖传感器植入 9 名 I 型糖尿病患者的腹部皮下组织，植入时间为 3 天（n = 2）和 7 天（n = 7）。事后进行单点校准，或者每天早餐前一次，或者每天早餐和晚餐前两次，或者每天每餐前三次。每天早上早餐时进行两点校准。结果：当使用单点校准对系统进行校准时，Clarke 误差网格 A 区和 B 区中存在的点的百分比明显更高。每天饭前使用两次单点校准实际上与三次单点校准一样准确。结论：本研究证明了校准连续血糖监测系统的简单方法的可行性。 (C) 2002 年，Elsevier Science B.V. 出版
Calibration, i.e. the transformation in real time of the signal I(t) generated by the glucose sensor at time t into an estimation of glucose concentration G(t), represents a key issue for the development of a continuous glucose monitoring system. Objective: To compare two calibration procedures. In the one-point calibration, which assumes that 10 is negligible, S is simply determined as the ratio I/G, and G(t) = I(t)/S. The two-point calibration consists in the determination of a sensor sensitivity S and of a background current I,, by plotting two values of the sensor signal versus the concomitant blood glucose concentrations. The subsequent estimation of G(t) is given by G(t) = (I(t)-I-o)/S. Research design and methods: A glucose sensor was implanted in the abdominal subcutaneous tissue of nine type I diabetic patients during 3 (n = 2) and 7 days (n = 7). The one-point calibration was performed a posteriori either once per day before breakfast, or twice per day before breakfast and dinner, or three times per day before each meal. The two-point calibration was performed each morning during breakfast. Results: The percentages of points present in zones A and B of the Clarke Error Grid were significantly higher when the system was calibrated using the one-point calibration. Use of two one-point calibrations per day before meals was virtually as accurate as three one-point calibrations. Conclusion: This study demonstrates the feasibility of a simple method for calibrating a continuous glucose monitoring system. (C) 2002 Published by Elsevier Science B.V.