Obestatin inhibits vasopressin secretion: evidence for a physiological action in the control of fluid homeostasis
Obestatin inhibits vasopressin secretion: evidence for a physiological action in the control of fluid homeostasis
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DOI：
10.1677/joe-07-0364
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发表时间：
2008-03-01
影响因子：
4
通讯作者：
White, Meghan M.
中科院分区：
文献类型：
--
作者：
Samson, Willis K.;Yosten, Gina L. C.;White, Meghan M.
Obestatin是生长激素释放肽前激素翻译后加工的产物，据报道在大脑中起抑制口渴的作用。我们通过检查obestatin对低血容量诱导的水和盐水饮用以及雄性大鼠血管加压素释放的影响来扩展我们对饮水的初步研究。脑室内给药obestatin显着抑制水，但不是生理盐水（0.3 M NaCl）饮用低血容量的挑战。奥贝他汀还以剂量相关的方式抑制脱水诱导的加压素分泌，而不影响血浆催产素水平。血管紧张素II诱导的血管加压素释放的衰减显着事先管理的obestatin。最后，中枢给药的抗血清特异性obestatin导致夸张的基础加压素释放和加压素反应增加过夜缺水。抗血清治疗还导致自由饮水和脱水后饮水显著增加。我们的结论是，这种产物的翻译后加工的生长激素释放肽激素原可能是一个重要的贡献者的生理调节offluid和电解质的稳态。
Obestatin, a product of post-translational processing of the ghrelin prohormone, has been reported to act in the brain to inhibit thirst. We extended our initial studies on water drinking by examining the effects of obestatin on hypovolemia-induced water and saline drinking and vasopressin release in male rats. Intracerebroventricular administration of obestatin significantly inhibited water, but not saline (0.3 M NaCl) drinking in response to a hypovolemic challenge. Obestatin also inhibited, in a dose-related fashion, dehydration-induced vasopressin secretion without affecting plasma oxytocin levels. Vasopressin release induced by central angiotensin II administration was attenuated significantly by prior administration of obestatin. Finally, central administration of an antiserum specific to obestatin resulted in an exaggerated basal vasopressin release and an increased vasopressin response to overnight water deprivation. Antiserum treatment also resulted in significantly increased ad libitum water drinking and drinking in response to dehydration. We conclude that this product of post-translational processing of the ghrelin prohormone may be an important contributor to the physiologic regulation offluid and electrolyte homeostasis.