A MURINE VIRUS (JHM) CAUSING DISSEMINATED ENCEPHALOMYELITIS WITH EXTENSIVE DESTRUCTION OF MYELIN : II. PATHOLOGY.
A MURINE VIRUS (JHM) CAUSING DISSEMINATED ENCEPHALOMYELITIS WITH EXTENSIVE DESTRUCTION OF MYELIN : II. PATHOLOGY.
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DOI：
10.1084/jem.90.3.195
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发表时间：
1949-08-31
期刊：
影响因子：
--
通讯作者：
Daniels JB
中科院分区：
文献类型：
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作者：
Bailey OT;Pappenheimer AM;Cheever FS;Daniels JB
已经描述了通过接种从患有自发性脑脊髓炎的小鼠获得的病毒材料而在动物中实验产生的病理变化。中枢神经系统病变最显着的特征是髓磷脂的广泛破坏。来自多种组织成分的巨细胞是早期病变的特征。大多数情况下，肝脏是局灶性坏死的所在地。一些小鼠经静脉途径大剂量感染后，肝脏出现大面积坏死，并出现脂肪浸润和钙化。淋巴组织中偶尔发现巨细胞，但其他器官未见明显变化。病变中未显示出内含物或基体。将小鼠病毒接种到仓鼠体内也会产生类似的损伤。在大鼠中，病变具有更慢性的特征。讨论了这种疾病与人类和动物的其他脱髓鞘疾病的关系。
A description has been given of the pathologic changes produced experimentally in animals by the inoculation of a virus material obtained from a mouse with spontaneous encephalomyelitis. The most distinctive feature of the lesions in the central nervous system is the widespread destruction of myelin. Giant cells derived from a variety of tissue elements characterize the early lesions. The liver in the majority of cases is the seat of focal necrosis. In some mice, infected with large doses by the intravenous route, there is produced massive necrosis of the liver, with fat infiltration and calcification. Giant cells are occasionally found in lymphatic tissue, but no significant changes were noted in other organs. Inclusions or elementary bodies were not demonstrated in the lesions. Similar lesions were produced by the inoculation of mouse virus into hamsters. In rats, the lesions were of a more chronic character. The relation of this disease to other demyelinating diseases of man and animals is discussed.