Pain Anticipation Recruits the Mesolimbic System and Differentially Modulates Subsequent Recognition Memory
Pain Anticipation Recruits the Mesolimbic System and Differentially Modulates Subsequent Recognition Memory
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DOI：
10.1002/hbm.22497
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发表时间：
2014-09-01
影响因子：
4.8
通讯作者：
Bunzeck, Nico
中科院分区：
文献类型：
--
作者：
Bauch, Eva M.;Rausch, Vanessa H.;Bunzeck, Nico
将信息编码到长期记忆中的能力不是一个被动的过程，而是会受到动机因素的影响。虽然中脑边缘系统长期以来一直与奖励驱动的记忆增强有关，但处理厌恶事件的精确神经生物学及其对陈述性学习的影响仍不清楚。为了解决这个问题，人类受试者编码了一系列场景图像，这些图像与预测具有不同概率（0.2，0.5，0.8）的厌恶电击的线索相结合。随后，识别记忆的场景进行了测试，使用记住/知道的程序。在行为实验中，电击概率对熟悉度有线性影响，对回忆有倒u型影响。虽然在实验2（功能磁共振成像）中没有行为效应，但在神经水平上，海马中编码相关活动模仿了回忆特异性二次效应，而海马旁前回中的活动反映了实验1中明显的熟悉特异性线性关系。重要的是，即将到来的电击的可能性在黑质/腹侧被盖区中被线性编码，并且疼痛相关的大脑区域，例如小脑，对电击递送做出反应。我们的研究结果表明，预期初级厌恶事件招募人类中脑边缘系统和差异调制陈述性记忆功能，通过内侧颞叶结构。《脑地图》35：4594-4606，2014年。(C)2014 Wiley Periodicals，Inc.
The ability to encode information into long-term memory is not a passive process but can be influenced by motivational factors. While the mesolimbic system has long been associated with reward-driven memory enhancement, the precise neurobiology of processing aversive events and their effects on declarative learning remain unclear. To address this issue, human subjects encoded a series of scene images, which was combined with cues predicting an aversive electric shock with different probabilities (0.2, 0.5, 0.8). Subsequently, recognition memory for the scenes was tested using a remember/know procedure. In a behavioral experiment, shock probability had linear effects on familiarity and inverted u-shaped effects on recollection. While the behavioral effect was absent in experiment 2 (fMRI), at the neural level encoding-related activity in the hippocampus mimicked the recollection specific quadratic effect, whereas activity in the anterior parahippocampal gyrus mirrored the familiarity specific linear relationship that was evident in experiment 1. Importantly, the probability of upcoming shocks was linearly coded in the substantia nigra / ventral tegmental area, and pain associated brain regions, such as the insula, responded to shock delivery. Our results demonstrate that anticipating primary aversive events recruits the human mesolimbic system and differentially modulates declarative memory functions via medial temporal lobe structures. Hum Brain Mapp 35:4594-4606, 2014. (C) 2014 Wiley Periodicals, Inc.