Chronic vascular response after self-expanding nitinol stent implantation in superficial femoral arteries: a serial intravascular ultrasound analysis
Chronic vascular response after self-expanding nitinol stent implantation in superficial femoral arteries: a serial intravascular ultrasound analysis
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股浅动脉自膨式镍钛合金支架植入后的慢性血管反应：系列血管内超声分析
DOI：
10.1007/s12928-015-0371-z
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发表时间：
2016
影响因子：
3.2
通讯作者：
T. Masuyama
中科院分区：
文献类型：
--
作者：
Machiko Nishimura;K. Fujii;M. Fukunaga;D. Kawasaki;K. Miki;T. Saita;Tetsuo Horimatsu;Hiroto Tamaru;T. Imanaka;Y. Naito;T. Masuyama
自膨式镍钛合金支架（SENS）的机械性能和SENS对管壁的慢性生物刺激尚未得到充分研究。本研究使用连续容积血管内超声（IVUS）评价了股浅动脉（SFA）病变中SENS植入的机械血管反应。前瞻性入组了25例因原发性SFA病变计划置入SENS的症状性患者。在使用导丝通过后立即、术后立即和8个月随访时进行了系列IVUS研究。在支架展开后和随访时进行连续IVUS体积分析。平均支架、管腔和新生内膜面积计算为体积除以支架长度，并测量钙弧。在随访时，SENS的总体积增加了40.6%。与重度钙化病变相比，轻度钙化病变的慢性支架扩张往往更大，8个月随访时的平均新生内膜面积显著更大。因此，在第一和第二象限中，钙弧为0°的病变的平均晚期管腔面积损失显著大于第三和第四象限中的钙弧病变（分别为2.8 ± 7.2、1.3 ± 5.6、0.6 ± 5.9、1.2 ± 5.4、−0.8 ± 5.2 mm 2;p< 0.001）。在所有病变中，SENS持续扩大，内膜增生超过8个月。尽管动脉钙影响了随访期间的慢性支架扩张程度，但与SENS植入后钙化程度较低的病变相比，重度钙化病变中的新生内膜增殖较小。
The mechanical properties of the self-expanding nitinol stents (SENS) and chronic biological stimulation on the wall from the SENS have not been fully investigated. This study evaluated the mechanical vascular response to SENS implantation in superficial femoral artery (SFA) lesions using serial volumetric intravascular ultrasound (IVUS). Twenty-five symptomatic patients due to de novo SFA lesions scheduled for SENS placement were prospectively enrolled. Serial IVUS studies were performed immediately after crossing with a guidewire, immediately after the procedure, and at a 8-month follow-up. Serial IVUS volumetric analysis was conducted after stent deployment and at follow-up. Mean stent, lumen and neointimal areas were calculated as the volume divided by the stent length, and the calcium arc was measured. At follow-up, SENS had increased 40.6 % in overall volume. The chronic stent expansion tended to be larger, and the mean neointimal area at the 8-month follow-up was significantly larger in less calcified lesions compared to heavily calcified lesions. As a result, the mean late lumen area loss was significantly larger in lesions with calcium arcs of 0° and in the first and second quadrants than in those with calcium arcs in the third and fourth quadrants (2.8 ± 7.2, 1.3 ± 5.6, 0.6 ± 5.9, 1.2 ± 5.4, −0.8 ± 5.2 mm2, respectively;p< 0.001). SENSs continued to enlarge with intimal proliferation over 8 months in all lesions. Although arterial calcium affected the degree of chronic stent expansion during the follow-up period, neointimal proliferation was smaller in heavily calcified lesion compared to less calcified lesion following SENS implantation.
周围动脉疾病 (PAD) 的血运重建 - 血管内治疗和外科搭桥手术 -
DOI：
--
发表时间：
2007
期刊：
影响因子：
--
作者：
大西 健;et. al.;古森公浩;古森公浩
通讯作者：
古森公浩