HIV infection and risk of COVID-19 mortality: A meta-analysis.
HIV infection and risk of COVID-19 mortality: A meta-analysis.
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DOI：
10.1097/md.0000000000026573
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发表时间：
2021-07-02
期刊：
影响因子：
1.6
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Dong Y;Li Z;Ding S;Liu S;Tang Z;Jia L;Liu J;Liu Y
这项荟萃分析旨在评估人类免疫缺陷病毒感染与2019年冠状病毒病(新冠肺炎)死亡风险之间的关联。计算机检索PubMed、EMbase、中国国家知识基础设施、万方、重庆维普等数据库2019年12月1日至2021年1月31日期间有关艾滋病病毒感染与新冠肺炎死亡风险的文章。采用纽卡斯尔-渥太华量表(NOS)评价纳入研究的质量。Cochran q检验和I2统计量被量化以衡量异质性。计算优势比(OR)和95%可信区间(CI)，并以林地形式显示。通过亚组分析探讨异质性的来源。采用漏斗图、Begg检验和Egger检验评估潜在的发表偏倚。使用STATA软件11.0版对所有统计数据进行分析。我们纳入了10项研究，涉及18,122,370名新冠肺炎患者，其中41,113名感染艾滋病毒，18,081,257名未感染艾滋病毒。综合结果显示，感染艾滋病毒的人比未感染艾滋病毒的人死于新冠肺炎的风险更高(OR = 1.252，95%CI 1.027-1.524)。亚组分析显示，在美国(OR = 1.520，95%CI 1.252-1.845)和南非(OR = 1.122，95%CI 1.032-1.220)，感染艾滋病毒的人新冠肺炎死亡的风险高于未感染艾滋病毒的人；但在英国没有发现显著的关联(OR = 0.878，95%CI 0.657-1.174)。在新冠肺炎患者的临床治疗中，应将艾滋病病毒感染者作为重点人群，预防死亡风险。
This meta-analysis aimed to estimate the association of human immunodeficiency virus (HIV) infection and risk of coronavirus disease 2019 (COVID-19) mortality. We systematically retrieved articles published on HIV infection and risk of COVID-19 mortality through PubMed, EMBase, China National Knowledge Infrastructure, WanFang, and Chongqing VIP databases using a predefined search strategy from December 1, 2019 to January 31, 2021. Newcastle–Ottawa Scale (NOS) was used to assess the quality of the included studies. Cochran Q test and I2 statistics were quantified to measure heterogeneity. Odds ratio (OR) and 95% confidence intervals (CI) were computed and displayed in the form of forest plots. Subgroup analysis was performed to explore the source of heterogeneity. Funnel plot, Begg test, and Egger test were used to assess potential publication bias. Stata software version 11.0 was used to analyze all the statistical data. We included 10 studies with 18,122,370 COVID-19 patients, of whom 41,113 were with HIV infection and 18,081,257 were without HIV infection. The pooled overall results suggested that people living with HIV infection had a higher risk of mortality from COVID-19 than those without HIV infection (OR = 1.252, 95% CI 1.027–1.524). Subgroup analysis showed that people living with HIV infection had a higher risk of COVID-19 mortality than those without HIV infection in the United States (OR = 1.520, 95% CI 1.252–1.845) and in South Africa (OR = 1.122, 95% CI 1.032–1.220); however, no significant association was found in the United Kingdom (OR = 0.878, 95% CI 0.657–1.174). Patients with HIV infection should be the emphasis population to prevent the risk of mortality during the clinical treatment of COVID-19 patients.