Fascin actin-bundling protein 1 in human cancer: promising biomarker or therapeutic target?
Fascin actin-bundling protein 1 in human cancer: promising biomarker or therapeutic target?
复制标题
人类癌症中的肌成束蛋白肌动蛋白捆绑蛋白 1：有希望的生物标志物或治疗靶点？
DOI：
10.1016/j.omto.2020.12.014
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发表时间：
2021-03-26
期刊：
影响因子：
--
通讯作者：
Gao W
中科院分区：
文献类型：
--
作者：
Liu H;Zhang Y;Li L;Cao J;Guo Y;Wu Y;Gao W
束蛋白肌动蛋白捆绑蛋白1 （FSCN1）是一种高度保守的肌动蛋白捆绑蛋白，它将f -肌动蛋白微丝交联成紧密的平行束。FSCN1水平升高已在许多类型的人类癌症中被报道，并与侵袭性临床进展、不良预后和生存结果相关。FSCN1在癌细胞中的过表达与肿瘤的生长、迁移、侵袭和转移有关。目前，FSCN1被认为是多种癌症类型的候选生物标志物和潜在的治疗靶点。本研究的目的是简要介绍FSCN1基因及其蛋白结构，并阐明其肌动蛋白捆绑活性和生理功能。主要关注FSCN1在癌细胞中的作用及其上调机制和意义。本文综述了FSCN1作为新型生物标志物和人类癌症治疗靶点的最新研究进展。研究表明，FSCN1是一种不同寻常的生物标志物和潜在的癌症治疗靶点。FSCN1是一种肌动蛋白结合蛋白，在肿瘤的进展和转移中起重要作用。其表达与侵袭性临床病程和不良预后相关。本文就FSCN1在肿瘤中的作用及其靶向FSCN1在肿瘤治疗中的临床应用作一综述。
Fascin actin-bundling protein 1 (FSCN1) is a highly conserved actin-bundling protein that cross links F-actin microfilaments into tight, parallel bundles. Elevated FSCN1 levels have been reported in many types of human cancers and have been correlated with aggressive clinical progression, poor prognosis, and survival outcomes. The overexpression of FSCN1 in cancer cells has been associated with tumor growth, migration, invasion, and metastasis. Currently, FSCN1 is recognized as a candidate biomarker for multiple cancer types and as a potential therapeutic target. The aim of this study was to provide a brief overview of the FSCN1 gene and protein structure and elucidate on its actin-bundling activity and physiological functions. The main focus was on the role of FSCN1 and its upregulatory mechanisms and significance in cancer cells. Up-to-date studies on FSCN1 as a novel biomarker and therapeutic target for human cancers are reviewed. It is shown that FSCN1 is an unusual biomarker and a potential therapeutic target for cancer. As an actin-bundling protein, FSCN1 plays an important role in cancer progression and metastasis. Its expression has been correlated with an aggressive clinical course and poor prognosis. This review summarizes not only the role of FSCN1 in cancers but also its clinical application in cancer therapy by targeting FSCN1.
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影响因子：
3.8
作者：
Alam H;Bhate AV;Gangadaran P;Sawant SS;Salot S;Sehgal L;Dange PP;Chaukar DA;D'cruz AK;Kannanl S;Gude R;Kane S;Dalal SN;Vaidya MM
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影响因子：
5.2
作者：
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通讯作者：
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影响因子：
3.3
作者：
Adams, JC
通讯作者：
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