Enhanced expression of the sis and c-myc oncogenes in human meningiomas.
Enhanced expression of the sis and c-myc oncogenes in human meningiomas.
复制标题
DOI：
10.3171/jns.1990.72.5.0786
复制
发表时间：
1990-05
影响因子：
4.1
通讯作者：
K. Kazumoto;M. Tamura;H. Hoshino;Y. Yuasa
中科院分区：
文献类型：
--
作者：
K. Kazumoto;M. Tamura;H. Hoshino;Y. Yuasa
在19个人脑膜瘤（14个原发性和4个复发性肿瘤和1个肿瘤移植到无胸腺裸鼠），癌基因表达，扩增，重排和杂合性丢失的染色体22进行了检查。与非肿瘤脑组织相比，在研究的15个肿瘤中有6个（40%）sis癌基因表达超过5倍，在19个肿瘤中有12个（63%）c-myc癌基因表达超过5倍。sis基因在复发肿瘤中的表达低于原发病例，在间变性脑膜瘤细胞中未检测到表达。在一例脑膜瘤中发现sis基因重排。在5个信息杂合子病例中的2个中检测到22号染色体杂合性丢失。c-myc基因的表达在有杂合性缺失的病例中高于无杂合性缺失的病例。这些结果表明，sis和c-myc癌基因与致瘤性和c-myc可能会导致脑膜瘤通过假定的肿瘤抑制基因的损失。
In 19 human meningiomas (14 primary and four recurrent tumors and one tumor transplanted into athymic nude mice), oncogene expression, amplification, and rearrangement, and loss of heterozygosity on chromosome 22 were examined. Compared to nontumor brain tissue, there was greater than a fivefold expression of the sis oncogene in six (40%) of 15 tumors studied and of the c-myc oncogene in 12 (63%) of the total 19 tumors. Expression of the sis gene was lower in the recurrent tumors than in the primary cases, and there was no detectable expression in anaplastic meningioma cells. Rearrangement of the sis gene was found in one meningioma. Loss of heterozygosity on chromosome 22 was detected in two of the five informative heterozygous cases. Expression of the c-myc gene was higher in cases with a loss of heterozygosity than in those without. These results suggest that the sis and c-myc oncogenes are associated with tumorigenicity and that c-myc may induce meningiomas through loss of the putative tumor suppressor gene.