Molecular biology of trypanosome antigenic variation.
Molecular biology of trypanosome antigenic variation.
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锥虫抗原变异的分子生物学。
DOI：
10.1128/mr.49.2.107-125.1985
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
Rice-Ficht,AC
中科院分区：
文献类型：
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作者：
Donelson,JE;Rice-Ficht,AC
前言非洲锥虫基因组脱氧核糖核酸(DNA)重排对于这些寄生虫在其哺乳动物宿主的血液中的存在是必不可少的。在过去的6年里，这些DNA重排与锥虫逃避免疫系统的方式的关系已经成为相当多研究的焦点，导致研究和综述文章的爆炸性增长。这些报告揭示了许多关于逃避机制的有趣和独特的特征，然而，这些机制仍然只被部分了解。这项审查于1984年11月完成，将把过去两年的调查结果纳入许多其他方面(8、20、23、40、42、49、57、65、94、104、113、147、157)审查过的以前资料的内容中。此外，我们希望证明，就像最近的评论一样，这个生物系统是当代分子生物学技术应用于对非洲具有重大医学和经济意义的问题的一个伟大例子。非洲锥虫通过顺序表达一系列可变的表面糖蛋白或VSG(90)来逃避它们哺乳动物的免疫系统，这个过程被称为
INTRODUCTION Genomic deoxyribonucleic acid (DNA) rearrangements in African trypanosomes are essential for the existence of these parasites in the bloodstream of theirmammalian hosts. The relationship of these DNA rearrangements to the way in which trypanosomes evade the immune system has become the focus of considerable research during the past 6 years, with a resultant explosion of both research and review articles. These reports have revealed many interesting and unique features about the evasion mechanism which, never-theless, remains only partially understood. This review, completed in November 1984, will place the findings of the past 2 years into thecontext of earlier information as reviewed by many others (8, 20, 23, 40, 42, 49, 57, 65, 94, 104, 113, 147, 157). In addition, we hope to demonstrate, as have the more recent reviews,'that this biological system is a magnificent example of the application of contemporary molecular biology techniques to a problem of great medical and economic significance for Africa. African trypanosomes evade the immune system of their mammalian hosts by sequentially expressing a series of variable surface glycoproteins or VSGs (90), a process called