Comprehensive analysis of the genome transcriptome and proteome landscapes of three tumor cell lines.

Comprehensive analysis of the genome transcriptome and proteome landscapes of three tumor cell lines.
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DOI:
10.1186/gm387
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发表时间:
2012
期刊:
影响因子:
12.3
通讯作者:
Lundeberg J
Lundeberg J
中科院分区:
生物学1区
文献类型:
--
作者:
Akan P;Alexeyenko A;Costea PI;Hedberg L;Solnestam BW;Lundin S;Hällman J;Lundberg E;Uhlén M;Lundeberg J

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We here present a comparative genome, transcriptome and functional network analysis of three human cancer cell lines (A431, U251MG and U2OS), and investigate their relation to protein expression. Gene copy numbers significantly influenced corresponding transcript levels; their effect on protein levels was less pronounced. We focused on genes with altered mRNA and/or protein levels to identify those active in tumor maintenance. We provide comprehensive information for the three genomes and demonstrate the advantage of integrative analysis for identifying tumor-related genes amidst numerous background mutations by relating genomic variation to expression/protein abundance data and use gene networks to reveal implicated pathways.
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