Prognostic Factors in Malignant Sublingual Salivary Gland Tumors
Prognostic Factors in Malignant Sublingual Salivary Gland Tumors
复制标题
恶性舌下唾液腺肿瘤的预后因素
DOI：
10.1016/j.joms.2016.12.010
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发表时间：
2017-07-01
影响因子：
1.9
通讯作者：
Han, Zhengxue
中科院分区：
文献类型：
--
作者：
Liu, Yanbin;Li, Hong;Han, Zhengxue
目的：探讨舌下腺恶性肿瘤的预后因素及预后。材料与方法：对1997~2011年间收治的舌下腺恶性肿瘤患者进行回顾性队列研究。对年龄、性别、肿瘤分期、淋巴结分期、神经周围侵犯、切缘状况和淋巴管侵犯等预测变量进行了分析。结果：38例患者中，男性16例(42.1%)。年龄36~75岁，平均53岁。11例(28.9%)为T3-T4肿瘤，6例(15.8%)颈淋巴结阳性。5年复发率为18.4%。5年远处转移率为23.7%。多变量分析证实了患者年龄、N分期和舌活动受限对局部复发和5年死亡率的独立预测作用。结论：患者年龄、N分期和舌活动受限是恶性涎腺肿瘤局部复发和死亡的独立预测因素。(C)2016年美国口腔颌面外科医生协会
Purpose: The present study identified the prognostic factors and outcomes for malignant sublingual salivary gland tumors, which are rare.Materials and Methods: A retrospective cohort study of patients treated for malignant sublingual salivary gland tumors from 1997 to 2011 was performed. The predictor variables, including age, gender, tumor stage, nodal stage, perineural invasion, margin status, and lymphovascular invasion, were analyzed. The Cox regression model was used to determine the prognostic factors for locoregional recurrence, distant metastasis, and survival.Results: Of the 38 patients, 16 (42.1%) were men. Their mean age was 53 years (range 36 to 75). A total of 11 patients (28.9%) had T3-T4 tumors, and 6 (15.8%) had positive neck lymph nodes. The recurrence rate at 5 years was 18.4%. The distant metastasis rate at 5 years was 23.7%. Multivariable analysis confirmed the independent prognostic importance of patient age, N stage, and limited tongue mobility in locoregional recurrence and mortality at 5 years.Conclusions: Our results suggest that patient age, N stage, and limited tongue mobility are useful as independent predictors of locoregional recurrence and mortality in patients with malignant sublingual salivary gland tumors. (C) 2016 American Association of Oral and Maxillofacial Surgeons