Therapeutic doses of diazepam do not alter impulsive behavior in humans
Therapeutic doses of diazepam do not alter impulsive behavior in humans
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DOI：
10.1016/j.pbb.2004.06.011
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发表时间：
2004-09-01
影响因子：
3.6
通讯作者：
de Wit, H
中科院分区：
文献类型：
--
作者：
Reynolds, B;Richards, JB;de Wit, H
本研究检测了低剂量地西泮对健康志愿者冲动行为的影响。志愿者（N=35）参加了三个阶段的双盲随机设计，其中他们接受地西泮（5或10 mg）或安慰剂。根据Barratt Impulsiveness Scale-11（BIS-11）将志愿者分为高冲动和低冲动。每次服用胶囊一小时后，参与者完成情绪问卷和五个冲动任务：去/不去任务，延迟折扣任务，时间估计任务，停止任务和气球模拟风险任务（BART）。地西泮（5和10毫克）产生其原型镇静样情绪效应。然而，该药物并没有影响高或低BIS参与者的任何冲动行为指标的表现。这些结果表明，低剂量的地西泮，包括用于治疗的剂量，不会增加冲动行为。更高的剂量是否会增加冲动仍有待确定。(C)2004年爱思唯尔公司All rights reserved.
This study examined the effects of low, therapeutic doses of diazepam on several measures of impulsive behavior in healthy volunteers. Volunteers (N=35) participated in a three-session double-blind randomized design in which they received diazepam (5 or 10 mg) or placebo. The volunteers were classified as high and low impulsive based on the Barratt Impulsiveness Scale-11 (BIS-11). One hour after ingesting the capsule on each session, participants completed mood questionnaires and five impulsivity tasks: go/no-go task, delay discounting task, time estimation task, stop task, and the balloon analogue risk task (BART). Diazepam (5 and 10 mg) produced its prototypic sedative-like mood effects. However, the drug did not affect performance on any of the measures of impulsive behavior in either the high or low BIS participants. These results suggest that low doses of diazepam, including doses that are used therapeutically, do not increase impulsive behavior. Whether higher doses would increase impulsivity remains to be determined. (C) 2004 Elsevier Inc. All rights reserved.