Prospective study of body mass index and risk of stroke in apparently healthy women
Prospective study of body mass index and risk of stroke in apparently healthy women
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DOI：
10.1161/01.cir.0000161822.83163.b6
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发表时间：
2005-04-19
期刊：
影响因子：
37.8
通讯作者：
Buring, JE
中科院分区：
文献类型：
--
作者：
Kurth, T;Gaziano, JM;Buring, JE
背景-肥胖在美国是一种不断升级的流行病，其与冠心病的关系已被充分理解。几项研究发现，男性的体重指数（BMI）和中风之间的正相关，但与中风及其亚型的关联是不太清楚的women.Methods和Results-This是一个前瞻性队列研究39053名妇女参加妇女的健康研究。BMI测量为自我报告的体重（以千克为单位）除以身高（以米为单位）的平方。卒中事件是自我报告的，并经病历审查证实。我们使用考克斯比例风险模型来评估BMI和中风之间的关系。平均随访10年后，共发生432例卒中（347例缺血性，81例出血性，4例未确定）。我们发现，在7个BMI类别中，总卒中和缺血性卒中风险增加的趋势具有统计学意义。根据世界卫生组织的标准，与BMI >= 30 kg/m2的女性相比，肥胖女性（BMI >= 30 kg/m2）发生总卒中的风险比为1.50（95% CI 1.16 - 1.94），缺血性卒中的风险比为1.72（95% CI 1.30 - 2.28），出血性卒中的风险比为0.82（95% CI 0.43 - 1.58
Background-Obesity is an escalating pandemic in the United States, and its association with coronary heart disease is well understood. Several studies have found positive associations between body mass index (BMI) and stroke in men, but the association with stroke and its subtypes is less clear in women.Methods and Results-This was a prospective cohort study among 39 053 women participating in the Women's Health Study. BMI was measured as self-reported weight ( in kilograms) divided by height (in meters) squared. Incident stroke was self-reported and confirmed by medical record review. We used the Cox proportional hazards model to evaluate the association between BMI and stroke. After a mean follow-up of 10 years, a total of 432 strokes ( 347 ischemic, 81 hemorrhagic, and 4 undefined) occurred. We found a statistically significant trend for increased risk of total and ischemic stroke across 7 BMI categories. With World Health Organization criteria, women who were obese (BMI >= 30 kg/m(2)) had hazard ratios of 1.50 (95% CI 1.16 to 1.94) for total stroke, 1.72 (95% CI 1.30 to 2.28) for ischemic stroke, and 0.82 (95% CI 0.43 to 1.58) for hemorrhagic stroke compared with women with BMI