Congenital cerebellar dysplasia in White Leghorn chickes (Gallus gallus domesticus)
Congenital cerebellar dysplasia in White Leghorn chickes (Gallus gallus domesticus)
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白来亨鸡（Gallus gallus Domesticus）先天性小脑发育不良
DOI：
10.1080/03079457.2014.889277
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发表时间：
2014
期刊：
影响因子：
2.8
通讯作者：
Asumi Abe.
中科院分区：
文献类型：
--
作者：
Sayuri Nakamura;Kenji Ochiai;Hiroki Yabushita;Asumi Abe.
先天性小脑异常在鸟类中很少报道。我们检测了7只无特定病原体的白来窝鸡（Gallus Gallus domesticus）的小脑叶紊乱。在小脑中，异位皮质岛从深部皮层向髓质分布。特征性病变由小脑皮层的浦肯野细胞、分子层和颗粒细胞随机混合组成。免疫荧光分析显示浦肯野细胞具有随意延伸的树突，并且在病灶中缺乏伯格曼胶质纤维。聚合酶链反应未检出鸡细小病毒、禽流感病毒和禽类逆转录病毒。这是首次报道可能由遗传异常引起的鸡小脑发育不良。
Congenital cerebellar anomalies have been rarely reported in birds. We examined cerebellums with disorganized folia from seven specific-pathogen-free White Leghorn chickens (Gallus gallus domesticus). Islands of heterotopic cortex were distributed from the deeper cortices to the medulla in the cerebellum. The characteristic lesions were composed of randomly admixed components of the cerebellar cortex, including Purkinje cells, a molecular layer and granular cells. Immunofluorescent analysis revealed Purkinje cells with haphazardly extended dendrites and a lack of Bergmann's glial fibres in the foci. Chicken parvovirus, Aino virus and avian retrovirus were not detected in the affected birds by polymerase chain reaction. This is the first report of cerebellar dysplasia in chickens possibly caused by a genetic abnormality.