Natural selection on polymorphic malaria antigens and the search for a vaccine
Natural selection on polymorphic malaria antigens and the search for a vaccine
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DOI：
10.1016/s0169-4758(96)10077-6
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发表时间：
1997-01-01
期刊：
影响因子：
--
通讯作者：
Conway, DJ
中科院分区：
文献类型：
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作者：
Conway, DJ
大多数被鉴定为疟疾疫苗候选物的蛋白质抗原在天然寄生虫种群中是多态的。目前的观点是，疫苗必须基于抗原的保守区域，如果对这些区域的天然获得性免疫反应在人类中仅具有部分保护性，那么疫苗必须创造自然界中缺乏的东西。另一种观点是，成功的疫苗可能需要基于抗原的多种等位基因形式。大卫康威在这里表明，从过于悲观或不切实际的罐子，这种观点提供了积极的方式来确定保护性免疫的目标。
Most protein antigens identified as malaria vaccine candidates are polymorphic in natural parasite populations. Current opinion is that a vaccine must be based on conserved regions of antigens, and if naturally acquired immune responses to these regions are only partially protective in humans, then the vaccine must create what is lacking in Nature. An alternative view is that it successful vaccine might need to be based on multiple allelic forms of an antigen. David Conway here shows that, Jar from being too pessimistic or impractical, this view offers positive ways to identify targets of protective immunity.