Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima
Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima
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DOI：
10.1021/acs.jnatprod.7b00732
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发表时间：
2018-01-01
影响因子：
5.1
通讯作者：
Baker, Bill J.
中科院分区：
文献类型：
--
作者：
Thomas, Santana A. L.;von Salm, Jacqueline L.;Baker, Bill J.
在2013年南大洋的一次巡航中，我们在800米至950米深的海底采集了珊瑚Plumarella delicatissima的标本。从该珊瑚中分离得到5个新的呋喃二萜类化合物：keikipukalides A-E（1-5），已知的二萜pukalide aldehyde（6），和已知的去甲二萜ineleganidene（7）。这些Plumarella萜烯缺乏哺乳动物细胞毒性，而2-7在1.9和12 μ M之间显示出抗杜氏利什曼原虫的活性。通过一维和二维核磁共振光谱和质谱法进行了结构解析，并通过X射线晶体学证实了Keikipukalides A和E。
During a 2013 cruise in the Southern Ocean we collected specimens of the octocoral Plumarella delicatissima between 800 and 950 m depth. Five new furanocembranoid diterpenes, keikipukalides A-E (1-5), the known diterpene pukalide aldehyde (6), and the known norditerpenoid ineleganolide (7) were isolated from the coral. These Plumarella terpenes lack mammalian cytotoxicity, while 2-7 display activity against Leishmania donovani between 1.9 and 12 mu M. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy and mass spectrometry, and keikipukalides A and E were confirmed by X-ray crystallography.