Does nitric oxide contribute to the basal vasodilation of pregnancy in conscious rabbits?
Does nitric oxide contribute to the basal vasodilation of pregnancy in conscious rabbits?
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DOI：
10.1152/ajpregu.2001.281.5.r1624
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发表时间：
2001-11-01
影响因子：
2.8
通讯作者：
Giraud, GD
中科院分区：
文献类型：
--
作者：
Brooks, VL;Clow, KA;Giraud, GD
妊娠产生明显的全身性血管舒张，但其机制尚不清楚。在清醒的家兔中进行实验以测试增加的一氧化氮（NO）产生有助于增加血管传导性的假设，但该贡献在血管床之间变化。在家兔的升主动脉、上级肠系膜动脉、终末主动脉和/或股动脉周围植入主动脉和腔静脉导管和超声流量探头。首先在妊娠前（NP），然后在妊娠结束时（P），在家兔中测定静脉注射N-ω-硝基-L-精氨酸（L-NA; 20 mg/kg或递增剂量2、5、10、15和20 mg/kg）的血流动力学反应。L-NA组间动脉压升高相似，但以下反应更大（P
Pregnancy produces marked systemic vasodilation, but the mechanism is unknown. Experiments were performed in conscious rabbits to test the hypotheses that increased nitric oxide (NO) production contributes to the increased vascular conductance, but that the contribution varies among vascular beds. Rabbits were instrumented with aortic and vena caval catheters and ultrasonic flow probes implanted around the ascending aorta, superior mesenteric artery, terminal aorta, and/or a femoral artery. Hemodynamic responses to intravenous injection of N-omega-nitro-L-arginine (L-NA; 20 mg/kg or increasing doses of 2, 5, 10, 15, and 20 mg/kg) were determined in rabbits first before pregnancy (NP) and then at the end of gestation (P). L-NA produced similar increases in arterial pressure between groups, but the following responses were larger (P