Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration-Systematic Review of the Literature Focused on Experimental Studies in Rodent Models.
Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration-Systematic Review of the Literature Focused on Experimental Studies in Rodent Models.
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DOI：
10.1155/2017/7567958
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发表时间：
2017
影响因子：
4.3
通讯作者：
Zografos GC
中科院分区：
文献类型：
--
作者：
Papanikolaou IG;Katselis C;Apostolou K;Feretis T;Lymperi M;Konstadoulakis MM;Papalois AE;Zografos GC
间充质干细胞(MSCs)是一种很有吸引力的再生医学来源，因为它们可以通过微创方法轻松获得，并有可能在肝部分切除(PH)和急性或慢性肝损伤后促进肝脏再生(LG)和改善肝功能。使用MEDLINE数据库对截至2016年9月1日发表的文章进行了系统的文献综述。在不同的组合中使用的关键词如下：“间充质干细胞”、“移植”、“干细胞”、“脂肪组织来源的干细胞”、“骨髓来源的干细胞”、“部分肝切除”、“急性肝衰竭”、“慢性肝衰竭”、“肝纤维化”、“肝硬变”、“大鼠”、“小鼠”和“肝再生”。所有介绍的关键词分别在Mesh数据库中搜索，以控制相关性和术语的准确性和有效性。共确定了41篇可能纳入的文章，并对其进行了详细审查。经过严格的遴选过程，共排除了28篇文章，剩下13篇文章构成了本次系统评价的基础。骨髓间充质干细胞移植可促进LG，改善肝功能。此外，MSCs还具有向肝细胞样细胞分化，提高存活率，并通过旁分泌机制保护肝细胞的能力。骨髓间充质干细胞移植可能在PH和急、慢性肝损伤后LG的发生过程中起到积极的作用。它们可能代表着治疗切除后急性肝功能衰竭的一种新的治疗选择。
Mesenchymal stem cells (MSCs) are an attractive source for regenerative medicine because they are easily accessible through minimally invasive methods and have the potential to enhance liver regeneration (LG) and improve liver function, following partial hepatectomy (PH) and acute or chronic liver injury. A systematic review of the literature was conducted for articles published up to September 1st, 2016, using the MEDLINE database. The keywords that were used in various combinations were as follows: “Mesenchymal stem cells”, “transplantation”, “stem cells”, “adipose tissue derived stem cells”, “bone marrow-derived stem cells”, “partial hepatectomy”, “acute liver failure”, “chronic liver failure”, “liver fibrosis”, “liver cirrhosis”, “rats”, “mice”, and “liver regeneration”. All introduced keywords were searched for separately in MeSH Database to control relevance and terminological accuracy and validity. A total of 41 articles were identified for potential inclusion and reviewed in detail. After a strict selection process, a total of 28 articles were excluded, leaving 13 articles to form the basis of this systematic review. MSCs transplantation promoted LG and improved liver function. Furthermore, MSCs had the ability to differentiate in hepatocyte-like cells, increase survival, and protect hepatocytes by paracrine mechanisms. MSCs transplantation may provide beneficial effects in the process of LG after PH and acute or chronic liver injury. They may represent a new therapeutic option to treat posthepatectomy acute liver failure.