Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice
Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice
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DOI：
10.1126/science.abl6618
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发表时间：
2022-03-04
期刊：
影响因子：
56.9
通讯作者：
Sakurai, Takeshi
中科院分区：
文献类型：
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作者：
Hasegawa, Emi;Miyasaka, Ai;Sakurai, Takeshi
睡眠周期的特点是非快速眼动睡眠 (NREM) 和快速眼动睡眠 (REM) 交替。该循环产生的机制尚不完全清楚。我们发现，NREM 睡眠期间基底外侧杏仁核 (BLA) 中的多巴胺 (DA) 短暂增加会终止 NREM 睡眠并启动 REM 睡眠。 DA 作用于 BLA 中表达多巴胺受体 D2 (Drd2) 的神经元，诱导 NREM 到 REM 的转变。这种机制也在发作性睡病患者的猝倒发作中发挥着作用，即快速眼动睡眠对清醒的病理性侵入。这些结果表明 BLA 中的 DA 信号传导在启动 REM 睡眠中发挥着关键作用，并为睡眠周期的生成提供了神经元基础。
The sleep cycle is characterized by alternating non-rapid eye movement (NREM) and rapid eye movement (REM) sleeps. The mechanisms by which this cycle is generated are incompletely understood. We found that a transient increase of dopamine (DA) in the basolateral amygdala (BLA) during NREM sleep terminates NREM sleep and initiates REM sleep. DA acts on dopamine receptor D2 (Drd2)-expressing neurons in the BLA to induce the NREM-to-REM transition. This mechanism also plays a role in cataplectic attacks-a pathological intrusion of REM sleep into wakefulness-in narcoleptics. These results show a critical role of DA signaling in the BLA in initiating REM sleep and provide a neuronal basis for sleep cycle generation.