High anxiety is a predisposing endophenotype for loss of control over cocaine, but not heroin, self-administration in rats
High anxiety is a predisposing endophenotype for loss of control over cocaine, but not heroin, self-administration in rats
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DOI：
10.1007/s00213-011-2626-4
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发表时间：
2012-07-01
影响因子：
3.4
通讯作者：
Belin, David
中科院分区：
文献类型：
--
作者：
Dilleen, Ruth;Pelloux, Yann;Belin, David
虽然高度焦虑通常与药物成瘾有关，但其在这种疾病中的因果作用尚不清楚。鉴于海洛因和可卡因成瘾背后的可分离神经机制的有力证据，本研究调查了高焦虑是否预示着大鼠对静脉注射可卡因或海洛因自我给药失去控制的倾向。在延长静脉注射可卡因或海洛因之前，对64只大鼠进行了焦虑评估。高焦虑的大鼠，在种群的下四分之一，显示出更大的增加可卡因，而不是海洛因，自我给药与低焦虑的大鼠相比，在种群的上四分之一。焦虑得分也与可卡因自我给药程度的增加呈正相关。目前的数据表明，高度焦虑使大鼠容易失去对可卡因的控制，但不会失去对海洛因摄入的控制。因此，高度焦虑可能是兴奋剂而非阿片类药物自我管理升级的一种脆弱性特征。
Although high anxiety is commonly associated with drug addiction, its causal role in this disorder is unclear.In light of strong evidence for dissociable neural mechanisms underlying heroin and cocaine addiction, the present study investigated whether high anxiety predicts the propensity of rats to lose control over intravenous cocaine or heroin self-administration.Sixty-four rats were assessed for anxiety in the elevated plus-maze, prior to extended access to intravenous cocaine or heroin self-administration.High-anxious rats, identified in the lower quartile of the population, showed a greater escalation of cocaine, but not heroin, self-administration compared with low-anxious rats selected in the upper quartile of the population. Anxiety scores were also positively correlated with the extent of escalation of cocaine self-administration.The present data suggest that high anxiety predisposes rats to lose control over cocaine-but not heroin-intake. High anxiety may therefore be a vulnerability trait for the escalation of stimulant but not opiate self-administration.