Keratin 17 Expression Correlates with Tumor Progression and Poor Prognosis in Gastric Adenocarcinoma
Keratin 17 Expression Correlates with Tumor Progression and Poor Prognosis in Gastric Adenocarcinoma
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DOI：
10.1245/s10434-012-2437-9
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发表时间：
2012-10-01
影响因子：
3.7
通讯作者：
Oyama, Tetsunari
中科院分区：
文献类型：
--
作者：
Ide, Munenori;Kato, Toshihide;Oyama, Tetsunari
角蛋白17（K17）被认为是基底/肌上皮细胞角蛋白，并且已知在活化的角质形成细胞中是可诱导的。K17在胰胆管非粘液腺癌或基底细胞样乳腺癌中的高表达率以前已有报道。本研究应用组织芯片免疫组化染色技术，对192例胃癌患者的临床病理特征及预后意义进行了研究。分析上皮标志物包括K17、K14和K5/6，细胞周期相关蛋白p53、Ki-67和14-3-3 sigma，以及粘液表型标志物包括CD 10、CDX 2、MUC 5AC和MUC 6。K17的表达与淋巴结转移（P = 0.003）和肿瘤的分期（P = 0.014）呈正相关。K17表达与14-3-3 sigma表达（P < 0.001）和CD 10表达（P = 0.015）显著相关。K17阳性表达的胃癌患者的总生存率显著低于K17阴性表达的胃癌患者（50.5% vs.71.1%，P = 0.004）。单因素分析显示K17表达与胃癌患者的预后相关（P = 0.004），多因素分析显示K17表达是影响胃癌患者预后的独立因素（P = 0.049），K17表达与胃癌的进展相关，可作为胃癌患者预后不良的生物标志物。
Keratin 17 (K17) is regarded as a basal/myoepithelial cell keratin and is known to be inducible in activated keratinocytes. The high frequency of K17 expression in pancreaticobiliary nonmucinous adenocarcinoma or basal-like breast carcinoma has previously been described. However, its expression in gastric cancer (GC) is controversial.We investigated the clinicopathological features and prognostic significance of 192 patients with GC by immunohistochemical staining of tissue microarrays. Analysis of epithelial markers including K17, K14, and K5/6, cell cycle-associated proteins p53, Ki-67, and 14-3-3 sigma, and mucinous phenotype markers including CD10, CDX2, MUC5AC, and MUC6 was performed.Cytoplasmic expression of K17 was observed in 95 (49.5 %) of 192 patients with GC. K17 expression positively correlated with lymph node metastasis (P = 0.003) and advanced stages of the disease (P = 0.014). K17 expression was significantly correlated with 14-3-3 sigma expression (P < 0.001) and CD10 expression (P = 0.015). The overall survival rates of patients with K17-positive GC were significantly lower than those with negative K17 expression (50.5 vs. 71.1 %, P = 0.004). Univariate analysis revealed that K17 expression confers a poor prognosis in patients with GC (P = 0.004), and it was also an independent prognostic factor in multivariate analysis (P = 0.049).K17 expression is correlated with tumor progression in GC and may serve as a biomarker for poor prognosis.