Beta Activity in the Subthalamic Nucleus During Sleep in Patients with Parkinson's Disease
Beta Activity in the Subthalamic Nucleus During Sleep in Patients with Parkinson's Disease
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DOI：
10.1002/mds.22351
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发表时间：
2009-01-30
影响因子：
8.6
通讯作者：
Artieda, Julio
中科院分区：
文献类型：
--
作者：
Urrestarazu, Elena;Iriarte, Jorge;Artieda, Julio
帕金森病(PD)患者丘脑底核局部场电位的记录，通过植入刺激器来治疗该疾病的运动症状，显示在贝塔范围内的显著基础(“关”)活动，该活动在多巴胺能治疗后减弱。最近的一项研究描述了快速眼动(REM)睡眠期间帕金森患者特征的改善。我们首次描述了帕金森病患者不同睡眠阶段下丘脑亚核(STN)活动的变化，特别是对β带的兴趣。对10例帕金森病患者进行了STN脑深部电刺激治疗。通过刺激电极记录清醒(关机)和不同睡眠阶段的丘脑局部场电位(LFP)。在阶段2和慢波睡眠中，记录到的β活动显著降低。在REM睡眠期间，β功率值与觉醒值相似，甚至更高。这些发现表明，STN的活动在不同的睡眠阶段受到调节和修饰。快速眼动睡眠中增加的β活动是一个新的但出人意料的发现，需要进一步的分析。(C)2008年流动无序社会
The recordings of local field potentials in the subthalamic nucleus in patients with Parkinson's disease (PD), carried Out through the Stimulators implanted to treat the motor symptoms of the disease, show a prominent basal ("off") activity in the beta range, which is attenuated after dopaminergic therapy. A recent study described improvement of parkinsonian features during rapid eyes movements (REM) sleep. We describe, for the first time, the changes in activity of the subthlamic nucleus (STN) during different sleep stages in Parkinson's disease with special interest in the beta band. Ten patients with PD treated with deep brain stimulation of the STN were studied. Subthalamic local field potentials (LFPs) were recorded through the stimulation electrodes during wakefulness ("off" medication) and different sleep stages. In Stage 2 and slow-wave sleep, a significant decrease of beta activity was recorded. During REM sleep, beta power values were similar to wakefulness values or even higher. These findings indicate that STN activity is modulated and modified during different sleep stages. The increased beta activity during REM sleep is a new but unexpected finding, which requires further analysis. (C) 2008 Movement Disorder Society